(E)-3-{3,5-Dimethyl-4-octadecanoyl-1-[(E)-(3-phenyl-acryloyl)]-1H-pyrrol-2-yl}-acrylic acid benzyl ester

Base Information

• Chemical Name: (E)-3-{3,5-Dimethyl-4-octadecanoyl-1-[(E)-(3-phenyl-acryloyl)]-1H-pyrrol-2-yl}-acrylic acid benzyl ester
• CAS No.: 185696-48-4
• Molecular Formula: C₄₃H₅₇NO₄
• Molecular Weight: 651.93
• Mol file: 185696-48-4.mol

Synonyms:(E)-3-{3,5-Dimethyl-4-octadecanoyl-1-[(E)-(3-phenyl-acryloyl)]-1H-pyrrol-2-yl}-acrylic acid benzyl ester

Chemical Property of (E)-3-{3,5-Dimethyl-4-octadecanoyl-1-[(E)-(3-phenyl-acryloyl)]-1H-pyrrol-2-yl}-acrylic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-3-{3,5-Dimethyl-4-octadecanoyl-1-[(E)-(3-phenyl-acryloyl)]-1H-pyrrol-2-yl}-acrylic acid benzyl ester

There total 7 articles about (E)-3-{3,5-Dimethyl-4-octadecanoyl-1-[(E)-(3-phenyl-acryloyl)]-1H-pyrrol-2-yl}-acrylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

Cinnamoyl chloride (102-92-1,17082-09-6) + (E)-3-(3,5-Dimethyl-4-octadecanoyl-1H-pyrrol-2-yl)-acrylic acid benzyl ester (185696-46-2) → (E)-3-{3,5-Dimethyl-4-octadecanoyl-1-[(E)-(3-phenyl-acryloyl)]-1H-pyrrol-2-yl}-acrylic acid benzyl ester (185696-48-4)

Guidance literature:

With sodium hydroxide; tetrabutylammomium bromide; water; In diethyl ether; dichloromethane; for 0.5h; Heating;

DOI:10.1002/ardp.19963291103

Reference yield:

3,5-dimethyl-4-octadecanoyl-pyrrole-2-carboxylic acid ethyl ester (36332-79-3) → (E)-3-{3,5-Dimethyl-4-octadecanoyl-1-[(E)-(3-phenyl-acryloyl)]-1H-pyrrol-2-yl}-acrylic acid benzyl ester (185696-48-4)

Guidance literature:

Multi-step reaction with 5 steps

1: 20percent aq. KOH / ethanol / 2 h / Heating

2: 0.33 h / 160 - 170 °C

3: 60 percent / POCl₃ / benzene / 2 h / Ambient temperature

4: 1) PPh₃ / 1) benzene, r.t., 10 min, reflux, 30 min, 2) benzene, CH₂Cl₂, 24 h

5: 47 percent / Bu₄NBr, NaOH, H₂O / diethyl ether; CH₂Cl₂ / 0.5 h / Heating

With potassium hydroxide; sodium hydroxide; tetrabutylammomium bromide; water; triphenylphosphine; trichlorophosphate; In diethyl ether; ethanol; dichloromethane; benzene;

DOI:10.1002/ardp.19963291103

Reference yield:

3,5-dimethyl-4-octadecanoylpyrrole-2-carboxylic acid (161559-70-2) → (E)-3-{3,5-Dimethyl-4-octadecanoyl-1-[(E)-(3-phenyl-acryloyl)]-1H-pyrrol-2-yl}-acrylic acid benzyl ester (185696-48-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 0.33 h / 160 - 170 °C

2: 60 percent / POCl₃ / benzene / 2 h / Ambient temperature

3: 1) PPh₃ / 1) benzene, r.t., 10 min, reflux, 30 min, 2) benzene, CH₂Cl₂, 24 h

4: 47 percent / Bu₄NBr, NaOH, H₂O / diethyl ether; CH₂Cl₂ / 0.5 h / Heating

With sodium hydroxide; tetrabutylammomium bromide; water; triphenylphosphine; trichlorophosphate; In diethyl ether; dichloromethane; benzene;

DOI:10.1002/ardp.19963291103

upstream raw materials:

Cinnamoyl chloride

(E)-3-(3,5-Dimethyl-4-octadecanoyl-1H-pyrrol-2-yl)-acrylic acid benzyl ester

benzylacrylate

3,5-dimethyl-4-octadecanoyl-pyrrole-2-carboxylic acid ethyl ester