N-[(R)-2-((S)-4-Isopropyl-2-oxo-oxazolidine-3-carbonyl)-4-methyl-pentyl]-benzamide

Base Information

• Chemical Name: N-[(R)-2-((S)-4-Isopropyl-2-oxo-oxazolidine-3-carbonyl)-4-methyl-pentyl]-benzamide
• CAS No.: 406949-04-0
• Molecular Formula: C₂₀H₂₈N₂O₄
• Molecular Weight: 360.453
• Mol file: 406949-04-0.mol

Synonyms:N-[(R)-2-((S)-4-Isopropyl-2-oxo-oxazolidine-3-carbonyl)-4-methyl-pentyl]-benzamide

Chemical Property of N-[(R)-2-((S)-4-Isopropyl-2-oxo-oxazolidine-3-carbonyl)-4-methyl-pentyl]-benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[(R)-2-((S)-4-Isopropyl-2-oxo-oxazolidine-3-carbonyl)-4-methyl-pentyl]-benzamide

There total 1 articles about N-[(R)-2-((S)-4-Isopropyl-2-oxo-oxazolidine-3-carbonyl)-4-methyl-pentyl]-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

N-(chloromethyl)benzamide (38792-42-6) + (4S)-4-isopropyl-3-(4'-methylvaleryl)-2-oxazolidinone (134806-81-8) → N-[(R)-2-((S)-4-Isopropyl-2-oxo-oxazolidine-3-carbonyl)-4-methyl-pentyl]-benzamide (406949-04-0)

Guidance literature:

With TEA; titanium tetrachloride; In dichloromethane; at -10 ℃;

DOI:10.1039/b106368p

Reference yield: 82.0%

N-[(R)-2-((S)-4-Isopropyl-2-oxo-oxazolidine-3-carbonyl)-4-methyl-pentyl]-benzamide (406949-04-0) → (R)-2-(Benzoylamino-methyl)-4-methyl-pentanoic acid (210345-88-3)

Guidance literature:

With lithium hydroxide; dihydrogen peroxide; In tetrahydrofuran; at 0 ℃;

DOI:10.1039/b106368p

Reference yield:

N-[(R)-2-((S)-4-Isopropyl-2-oxo-oxazolidine-3-carbonyl)-4-methyl-pentyl]-benzamide (406949-04-0) → (2R)-([amino]methyl)-4-methylpentanoic acid (210345-89-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / aq. H₂O₂; LiOH / tetrahydrofuran / 0 °C

2: 86 percent / aq. HCl / acetic acid / 110 °C

With hydrogenchloride; lithium hydroxide; dihydrogen peroxide; In tetrahydrofuran; acetic acid;

DOI:10.1039/b106368p

upstream raw materials:

N-(chloromethyl)benzamide

(4S)-4-isopropyl-3-(4'-methylvaleryl)-2-oxazolidinone

Downstream raw materials:

(R)-2-(Benzoylamino-methyl)-4-methyl-pentanoic acid

(2R)-([amino]methyl)-4-methylpentanoic acid