4-{4-[7-(4-cyano-2-fluoro-3-trifluoromethyl-phenyl)-8-oxo-6-thioxo-5,7-diaza-spiro[3.4]oct-5-yl]-2-fluoro-phenyl}-N-methyl-butyramide

Base Information

Chemical Name:4-{4-[7-(4-cyano-2-fluoro-3-trifluoromethyl-phenyl)-8-oxo-6-thioxo-5,7-diaza-spiro[3.4]oct-5-yl]-2-fluoro-phenyl}-N-methyl-butyramide
CAS No.:1398045-87-8
Molecular Formula:C₂₅H₂₁F₅N₄O₂S
Molecular Weight:536.525
Hs Code.:

Synonyms:4-{4-[7-(4-cyano-2-fluoro-3-trifluoromethyl-phenyl)-8-oxo-6-thioxo-5,7-diaza-spiro[3.4]oct-5-yl]-2-fluoro-phenyl}-N-methyl-butyramide

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Chemical Property of 4-{4-[7-(4-cyano-2-fluoro-3-trifluoromethyl-phenyl)-8-oxo-6-thioxo-5,7-diaza-spiro[3.4]oct-5-yl]-2-fluoro-phenyl}-N-methyl-butyramide

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Technology Process of 4-{4-[7-(4-cyano-2-fluoro-3-trifluoromethyl-phenyl)-8-oxo-6-thioxo-5,7-diaza-spiro[3.4]oct-5-yl]-2-fluoro-phenyl}-N-methyl-butyramide

There total 6 articles about 4-{4-[7-(4-cyano-2-fluoro-3-trifluoromethyl-phenyl)-8-oxo-6-thioxo-5,7-diaza-spiro[3.4]oct-5-yl]-2-fluoro-phenyl}-N-methyl-butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1146975-20-3
4-(4-(1-Cyanocyclobutylamino)-2-fluorophenyl)-N-methylbutanamide

: 1311158-94-7
C₉H₂F₄N₂S

: 1398045-87-8
4-{4-[7-(4-cyano-2-fluoro-3-trifluoromethyl-phenyl)-8-oxo-6-thioxo-5,7-diaza-spiro[3.4]oct-5-yl]-2-fluoro-phenyl}-N-methyl-butyramide

Guidance literature:: 4-(4-(1-Cyanocyclobutylamino)-2-fluorophenyl)-N-methylbutanamide; C₉H₂F₄N₂S; In N,N-dimethyl-formamide; at 20 ℃;

With hydrogenchloride; methanol; In N,N-dimethyl-formamide; for 2h; Reflux;

Reference yield:

: 1146975-15-6
Trimethyl 1-(2-fluoro-4-nitrophenyl)propane-1,1,3-tricarboxylate

: 1398045-87-8
4-{4-[7-(4-cyano-2-fluoro-3-trifluoromethyl-phenyl)-8-oxo-6-thioxo-5,7-diaza-spiro[3.4]oct-5-yl]-2-fluoro-phenyl}-N-methyl-butyramide

Guidance literature:: Multi-step reaction with 5 steps

1.1: water; sodium chloride / dimethyl sulfoxide / 24 h / 155 °C / Inert atmosphere

2.1: ammonium chloride; iron / water; methanol / 1 h / 90 °C / Inert atmosphere

3.1: methanol / 72 h / 20 °C / Inert atmosphere

4.1: zinc(II) chloride / 1,4-dioxane / 3 h / 20 °C

5.1: N,N-dimethyl-formamide / 20 °C

5.2: 2 h / Reflux

With water; iron; ammonium chloride; sodium chloride; zinc(II) chloride; In 1,4-dioxane; methanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1146975-16-7
Methyl 4-(2-fluoro-4-nitrophenyl)butanoate

: 1398045-87-8
4-{4-[7-(4-cyano-2-fluoro-3-trifluoromethyl-phenyl)-8-oxo-6-thioxo-5,7-diaza-spiro[3.4]oct-5-yl]-2-fluoro-phenyl}-N-methyl-butyramide

Guidance literature:: Multi-step reaction with 4 steps

1.1: ammonium chloride; iron / water; methanol / 1 h / 90 °C / Inert atmosphere

2.1: methanol / 72 h / 20 °C / Inert atmosphere

3.1: zinc(II) chloride / 1,4-dioxane / 3 h / 20 °C

4.1: N,N-dimethyl-formamide / 20 °C

4.2: 2 h / Reflux

With iron; ammonium chloride; zinc(II) chloride; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;