N'-(2-(2-chloro-6-fluorophenyl)-7-oxo-3,6-bis{[2-(trimethylsilyl)ethoxy]methyl}-6,7-dihydro-3H-benzo[h]imidazo[4,5-f]isoquinolin-9-yl)-N,N-dimethylsulfamide

Base Information

Chemical Name:N'-(2-(2-chloro-6-fluorophenyl)-7-oxo-3,6-bis{[2-(trimethylsilyl)ethoxy]methyl}-6,7-dihydro-3H-benzo[h]imidazo[4,5-f]isoquinolin-9-yl)-N,N-dimethylsulfamide
CAS No.:960214-20-4
Molecular Formula:C₃₄H₄₅ClFN₅O₅SSi₂
Molecular Weight:746.45
Hs Code.:

N'-(2-(2-chloro-6-fluorophenyl)-7-oxo-3,6-bis{[2-(trimethylsilyl)ethoxy]methyl}-6,7-dihydro-3H-benzo[h]imidazo[4,5-f]isoquinolin-9-yl)-N,N-dimethylsulfamide

Synonyms:N'-(2-(2-chloro-6-fluorophenyl)-7-oxo-3,6-bis{[2-(trimethylsilyl)ethoxy]methyl}-6,7-dihydro-3H-benzo[h]imidazo[4,5-f]isoquinolin-9-yl)-N,N-dimethylsulfamide

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Chemical Property of N'-(2-(2-chloro-6-fluorophenyl)-7-oxo-3,6-bis{[2-(trimethylsilyl)ethoxy]methyl}-6,7-dihydro-3H-benzo[h]imidazo[4,5-f]isoquinolin-9-yl)-N,N-dimethylsulfamide

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Technology Process of N'-(2-(2-chloro-6-fluorophenyl)-7-oxo-3,6-bis{[2-(trimethylsilyl)ethoxy]methyl}-6,7-dihydro-3H-benzo[h]imidazo[4,5-f]isoquinolin-9-yl)-N,N-dimethylsulfamide

There total 2 articles about N'-(2-(2-chloro-6-fluorophenyl)-7-oxo-3,6-bis{[2-(trimethylsilyl)ethoxy]methyl}-6,7-dihydro-3H-benzo[h]imidazo[4,5-f]isoquinolin-9-yl)-N,N-dimethylsulfamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 960214-17-9
9-bromo-2-(2-chloro-6-fluorophenyl)-3,6-bis{[2-(trimethylsilyl)ethoxy]methyl}-3,6-dihydro-7H-benzo[h]imidazo[4,5-f]isoquinolin-7-one

: 3984-14-3
N,N-dimethylsulfamide

: 960214-20-4
N'-(2-(2-chloro-6-fluorophenyl)-7-oxo-3,6-bis{[2-(trimethylsilyl)ethoxy]methyl}-6,7-dihydro-3H-benzo[h]imidazo[4,5-f]isoquinolin-9-yl)-N,N-dimethylsulfamide

Guidance literature:: With caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 100 ℃;

Reference yield:

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 960214-20-4
N'-(2-(2-chloro-6-fluorophenyl)-7-oxo-3,6-bis{[2-(trimethylsilyl)ethoxy]methyl}-6,7-dihydro-3H-benzo[h]imidazo[4,5-f]isoquinolin-9-yl)-N,N-dimethylsulfamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium tert-butylate / tetrahydrofuran / 0.75 h / 20 °C

1.2: 20 °C

2.1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 100 °C

With potassium tert-butylate; caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane;