3984-14-3

Basic information

• Product Name: N,N-Dimethylsulfamide
• Synonyms: dimethylsulfamide;N,N-DIMETHYLSULFAMIDE;N,N-DIMETHYLSULFAMOYLAMIDE;[methyl(sulfamoyl)amino]methane;N.N-DiMethylsu;EOS-60610
• CAS NO: 3984-14-3
• Molecular Formula: C₂H₈N₂O₂S
• Molecular Weight: 124.16
• Product Categories: API intermediates;CHIRAL CHEMICALS;sulfonyl compound;Aliphatics;Amines;Sulfur & Selenium Compounds
• Mol File: 3984-14-3.mol
• Article Data: 12

Chemical Properties

• Melting Point: 95-96
• Boiling Point: 216.9 °C at 760 mmHg
• Flash Point: 85 °C
• Appearance: White solid
• Density: 1.327 g/cm³
• Vapor Pressure: 0.137mmHg at 25°C
• Refractive Index: 1.502
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Acetone (Slightly), DMSO (Slightly), Methanol (Slightly)
• PKA: 11.41±0.60(Predicted)
• CAS DataBase Reference: N,N-Dimethylsulfamide(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-Dimethylsulfamide(3984-14-3)
• EPA Substance Registry System: N,N-Dimethylsulfamide(3984-14-3)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 3984-14-3(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

N,N-Dimethylsulfamide is a byproduct of Tolylfluanide (T536730) fungicide decomposition found in some waters. Upon ozonization it becomes a precursor for carcinogenic Nitrosodimethylamine (N525625). Otherwise N,N-Dimethylsulfamide is a versatile reactant used in various syntheses such as preparation of N-sulfonylbenzaldimines in copper-catalyzed aza-Friedel-Crafts reactions with 1-methylindole.

InChI:InChI=1/C2H8N2O2S/c1-4(2)7(3,5)6/h1-2H3,(H2,3,5,6)

Upstream product

• 13360-57-1 dimethylamino sulfonyl chloride 
• 124-40-3 dimethyl amine 
• 29777-22-8 N,N-Dimethyl-N'-(trimethylsilyl)sulfamid 

Downstream Products

• 7291-02-3 3-nitro-N,N-dimethylbenzamide 
• 18925-69-4 N,N-dimethyl-2-phenylacetamide 
• 611-74-5 N,N-dimethylbenzamide 
• 14062-80-7 N,N-dimethyl-4-chlorobenzamide 
• 6526-67-6 N,N-dimethyl-o-chlorobenzamide 
• 1030-69-9 3-Dimethylaminosulfonyl-1-(4-dimethylamino-phenyl)-harnstoff 
• 124-40-3 dimethyl amine 
• 1443431-31-9 5-chloro-4-{[(5-chloro-6-cyclopropylpyridin-3-yl)oxy]methyl}-N[(dimethylamino)sulfonyl]-2-fluorobenzamide diethylamine salt 
• 1443430-96-3 4-{[4-chloro-3-(trifluoromethyl)phenoxy]methyl}-N-[(dimethylamino)sulfonyl]benzamide 
• 1443430-98-5 4-{[3-chloro-4-(trifluoromethyl)phenoxy]methyl}-N-[(dimethylamino)sulfonyl]benzamide 
• 1443432-56-1 N-[(dimethylamino)sulfonyl]-2,5-difluoro-4-methylbenzamide 
• 1443430-94-1 N-[(dimethylamino)sulfonyl]-2,4,5-triifluorobenzamide 
• 1443431-08-0 4-[(5-chloro-6-isopropoxypyridin-3-yl)methoxy]-N-[(dimethylamino)sulfonyl]-2,5-difluorobenzamide 
• 1443431-21-7 N-[(dimethylamino)sulfonyl]-4-fluorobenzamide 

Relevant articles and documents

Photochemically Mediated Nickel-Catalyzed Synthesis of N-(Hetero)aryl Sulfamides

A general method for the N-arylation of sulfamides with aryl bromides is described. The protocol leverages a dual-catalytic system, with [Ir(ppy)2(dtbbpy)]PF6 as a photosensitizer, NiBr2·glyme as a precatalyst, and 1,8-diazabicyclo(5.4.0)undec-7-ene (DBU)

SUBSTITUTED PYRAZOLO[1,5-A] PYRIDINE AS TROPOMYOSIN RECEPTOR KINASE (TRK) INHIBITORS

The present application relates to a series of substituted pyrazolo[1,5-a]pyridine compounds, their use as tropomyosin receptor kinase (Trk) family protein kinase inhibitors., method of making and pharmaceutical compositions comprising such compounds.

N-AMINOSULFONYL BENZAMIDES

The invention relates to sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to a new sulphonamide Nav 1.7 inhibitors of formula (I) or a pharmaceutically acceptable salt thereof, wherein Z, R1a, R1b, R2, R3, R4 and R5 are as defined in the description. Nay 1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain