(1s,4s)-N,N-dimethyl-4-(4-octylphenyl)-N-propylcyclohexanaminium iodide

Base Information

Chemical Name:(1s,4s)-N,N-dimethyl-4-(4-octylphenyl)-N-propylcyclohexanaminium iodide
CAS No.:1353879-99-8
Molecular Formula:C₂₅H₄₄N*I
Molecular Weight:485.536
Hs Code.:

Synonyms:(1s,4s)-N,N-dimethyl-4-(4-octylphenyl)-N-propylcyclohexanaminium iodide

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Chemical Property of (1s,4s)-N,N-dimethyl-4-(4-octylphenyl)-N-propylcyclohexanaminium iodide

Chemical Property:

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Technology Process of (1s,4s)-N,N-dimethyl-4-(4-octylphenyl)-N-propylcyclohexanaminium iodide

There total 8 articles about (1s,4s)-N,N-dimethyl-4-(4-octylphenyl)-N-propylcyclohexanaminium iodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1353879-93-2
(1s,4s)-N-methyl-4-(4-octylphenyl)-N-propylcyclohexanamine

: 74-88-4
methyl iodide

: 1353879-99-8
(1s,4s)-N,N-dimethyl-4-(4-octylphenyl)-N-propylcyclohexanaminium iodide

Guidance literature:: In acetonitrile; for 2h; Reflux;
DOI:10.1016/j.bmc.2011.11.011

Reference yield:

: 4746-97-8
cyclohexanedione monoethylene ketal

: 1353879-99-8
(1s,4s)-N,N-dimethyl-4-(4-octylphenyl)-N-propylcyclohexanaminium iodide

Guidance literature:: Multi-step reaction with 7 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.17 h / -78 °C

1.2: -78 - 0 °C

2.1: toluene-4-sulfonic acid / toluene / 1 h / 65 °C

3.1: palladium 10% on activated carbon; hydrogen / ethanol / 20 h

4.1: water; acetic acid / 2 h / 65 °C

5.1: methanol / 1 h / 20 °C

5.2: 20 h / -78 - 20 °C

6.1: formic acid / methanol / 6 h / Reflux

6.2: pH Ca_. 12

7.1: acetonitrile / 2 h / Reflux

With n-butyllithium; formic acid; palladium 10% on activated carbon; water; hydrogen; toluene-4-sulfonic acid; acetic acid; In tetrahydrofuran; methanol; ethanol; hexane; toluene; acetonitrile; 6.1: Eschweiler-Clarke reaction;
DOI:10.1016/j.bmc.2011.11.011

Reference yield:

: 1353879-53-4
8-(4-octylphenyl)-1,4-dioxaspiro[4.5]decan-8-ol

: 1353879-99-8
(1s,4s)-N,N-dimethyl-4-(4-octylphenyl)-N-propylcyclohexanaminium iodide

Guidance literature:: Multi-step reaction with 6 steps

1.1: toluene-4-sulfonic acid / toluene / 1 h / 65 °C

2.1: palladium 10% on activated carbon; hydrogen / ethanol / 20 h

3.1: water; acetic acid / 2 h / 65 °C

4.1: methanol / 1 h / 20 °C

4.2: 20 h / -78 - 20 °C

5.1: formic acid / methanol / 6 h / Reflux

5.2: pH Ca_. 12

6.1: acetonitrile / 2 h / Reflux

With formic acid; palladium 10% on activated carbon; water; hydrogen; toluene-4-sulfonic acid; acetic acid; In methanol; ethanol; toluene; acetonitrile; 5.1: Eschweiler-Clarke reaction;
DOI:10.1016/j.bmc.2011.11.011