(1R,2R)-2-(2-methoxyphenyl)cyclopropane-1-carboxylic acid

Base Information

Chemical Name:(1R,2R)-2-(2-methoxyphenyl)cyclopropane-1-carboxylic acid
CAS No.:5034-03-7
Molecular Formula:C₁₁H₁₂O₃
Molecular Weight:192.214
Hs Code.:
European Community (EC) Number:872-311-7

Synonyms:(1R,2R)-2-(2-methoxyphenyl)cyclopropane-1-carboxylic acid;5034-03-7;(1R,2R)-2-(2-Methoxyphenyl)cyclopropanecarboxylic Acid;110826-01-2;trans-2-(2-Methoxyphenyl)cyclopropanecarboxylic Acid;SCHEMBL17103923;AC8866;AC9144;AKOS026745275;EN300-199270;EN300-250467;Z2242045589;rac-(1R,2R)-2-(2-methoxyphenyl)cyclopropane-1-carboxylic acid;rel-(1R,2R)-2-(2-Methoxyphenyl)cyclopropane-1-carboxylic acid;(1R,2R)-2-(2-Methoxyphenyl)cyclopropanecarboxylic acid, AldrichCPR

Suppliers and Price of (1R,2R)-2-(2-methoxyphenyl)cyclopropane-1-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of (1R,2R)-2-(2-methoxyphenyl)cyclopropane-1-carboxylic acid

Chemical Property:

XLogP3:1.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:192.078644241
Heavy Atom Count:14
Complexity:227

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC=CC=C1C2CC2C(=O)O
Isomeric SMILES:COC1=CC=CC=C1[C@@H]2C[C@H]2C(=O)O

Technology Process of (1R,2R)-2-(2-methoxyphenyl)cyclopropane-1-carboxylic acid

There total 14 articles about (1R,2R)-2-(2-methoxyphenyl)cyclopropane-1-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: trans-2-(2-methoxyphenyl)cyclopropanecarboxylic acid methyl ester

: 5034-03-7
trans-[2-(2-methoxyphenyl)cyclopropane]carboxylic acid

Guidance literature:: trans-2-(2-methoxyphenyl)cyclopropanecarboxylic acid methyl ester; With water; sodium hydroxide; In methanol; at 20 ℃; for 3h;

With hydrogenchloride; In water;
DOI:10.1016/j.bmcl.2012.11.069

Reference yield: 97.0%

: 110826-31-8
(1R,2S)-N-<(R)-2-hydroxy-1-phenylethyl>-2-(2-methoxyphenyl)cyclopropanecarboxamide

: 5034-03-7
(1R,2S)-2-(2-methoxyphenyl)cyclopropanecarboxylic acid

Guidance literature:: With sulfuric acid; In 1,4-dioxane; at 100 ℃; for 24h;
DOI:10.1021/jm00396a014

Reference yield:

: 1011-54-7
2-methoxycinnamic acid

: 5034-03-7
(1R,2S)-2-(2-methoxyphenyl)cyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

2: 100 percent / Pd(OAc)2 / diethyl ether; CH₂Cl₂ / 1 h / -10 - -5 °C

3: 92 percent / NaOH / methanol

4: SOCl₂ / 0.75 h / 55 °C

5: 44 percent / Et₃N / CH₂Cl₂ / 1.) 0 deh C, 30 min, 2.) room temperature, overnight

6: 97 percent / H₂SO₄ / dioxane / 24 h / 100 °C

With sodium hydroxide; thionyl chloride; sulfuric acid; triethylamine; palladium diacetate; In 1,4-dioxane; methanol; diethyl ether; dichloromethane;
DOI:10.1021/jm00396a014