Carbamic acid, [2-(2-methoxyphenyl)cyclopropyl]-, 1,1-dimethylethyl ester, (1R-trans)-

Base Information

Chemical Name:Carbamic acid, [2-(2-methoxyphenyl)cyclopropyl]-, 1,1-dimethylethyl ester, (1R-trans)-
CAS No.:157518-47-3
Molecular Formula:C₁₅H₂₁NO₃
Molecular Weight:263.337
Hs Code.:
DSSTox Substance ID:DTXSID001126544

Synonyms:DTXSID001126544;Carbamic acid, [2-(2-methoxyphenyl)cyclopropyl]-, 1,1-dimethylethyl ester, (1R-trans)-;157518-47-3

Suppliers and Price of Carbamic acid, [2-(2-methoxyphenyl)cyclopropyl]-, 1,1-dimethylethyl ester, (1R-trans)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Carbamic acid, [2-(2-methoxyphenyl)cyclopropyl]-, 1,1-dimethylethyl ester, (1R-trans)-

Chemical Property:

XLogP3:2.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:263.15214353
Heavy Atom Count:19
Complexity:324

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)OC(=O)NC1CC1C2=CC=CC=C2OC
Isomeric SMILES:CC(C)(C)OC(=O)N[C@@H]1C[C@H]1C2=CC=CC=C2OC

Technology Process of Carbamic acid, [2-(2-methoxyphenyl)cyclopropyl]-, 1,1-dimethylethyl ester, (1R-trans)-

There total 6 articles about Carbamic acid, [2-(2-methoxyphenyl)cyclopropyl]-, 1,1-dimethylethyl ester, (1R-trans)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1011-54-7
2-methoxycinnamic acid

: 157518-47-3
[(1R,2S)-2-(2-Methoxy-phenyl)-cyclopropyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: SOCl₂ / 2 h / Ambient temperature

2: 1.) NaH / 1) toluene, 30 min; 2) toluene, overnight

3: 73 percent / Pd(OAc)2 / CH₂Cl₂ / 3 h / 0 - 5 °C

4: 1.) titanium(IV) isopropoxide, benzyl alcohol, 2.) aq. NaOH / 1) 150 deg C, 30 min; 2) THF, MeOH, 2 h

5: 1.) ethyl chloroformate, Et₃N, 2.) aq. NaN₃ / 1) -10 deg C, acetone, 2 h; 2) -10 deg C, acetone, 1 h

6: 1) toluene, 90 deg C, 3 h; 2) reflux, 16 h

With titanium(IV) isopropylate; palladium diacetate; sodium hydroxide; thionyl chloride; sodium azide; chloroformic acid ethyl ester; sodium hydride; triethylamine; benzyl alcohol; In dichloromethane;

Reference yield:

: 118652-93-0
o-methoxycinnamoyl chloride

: 157518-47-3
[(1R,2S)-2-(2-Methoxy-phenyl)-cyclopropyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) NaH / 1) toluene, 30 min; 2) toluene, overnight

2: 73 percent / Pd(OAc)2 / CH₂Cl₂ / 3 h / 0 - 5 °C

3: 1.) titanium(IV) isopropoxide, benzyl alcohol, 2.) aq. NaOH / 1) 150 deg C, 30 min; 2) THF, MeOH, 2 h

4: 1.) ethyl chloroformate, Et₃N, 2.) aq. NaN₃ / 1) -10 deg C, acetone, 2 h; 2) -10 deg C, acetone, 1 h

5: 1) toluene, 90 deg C, 3 h; 2) reflux, 16 h

With titanium(IV) isopropylate; palladium diacetate; sodium hydroxide; sodium azide; chloroformic acid ethyl ester; sodium hydride; triethylamine; benzyl alcohol; In dichloromethane;

Reference yield:

: 157603-99-1
(E)-1-((1S,5R,7R)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-3-(2-methoxy-phenyl)-propenone

: 157518-47-3
[(1R,2S)-2-(2-Methoxy-phenyl)-cyclopropyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 73 percent / Pd(OAc)2 / CH₂Cl₂ / 3 h / 0 - 5 °C

2: 1.) titanium(IV) isopropoxide, benzyl alcohol, 2.) aq. NaOH / 1) 150 deg C, 30 min; 2) THF, MeOH, 2 h

3: 1.) ethyl chloroformate, Et₃N, 2.) aq. NaN₃ / 1) -10 deg C, acetone, 2 h; 2) -10 deg C, acetone, 1 h

4: 1) toluene, 90 deg C, 3 h; 2) reflux, 16 h

With titanium(IV) isopropylate; palladium diacetate; sodium hydroxide; sodium azide; chloroformic acid ethyl ester; triethylamine; benzyl alcohol; In dichloromethane;