(1R,2S)-2-(2-methoxyphenyl)cyclopropylamine

Base Information

Chemical Name:(1R,2S)-2-(2-methoxyphenyl)cyclopropylamine
CAS No.:110901-87-6
Molecular Formula:C₁₀H₁₃NO
Molecular Weight:163.219
Hs Code.:

Synonyms:(1R,2S)-2-(2-methoxyphenyl)cyclopropylamine

Suppliers and Price of (1R,2S)-2-(2-methoxyphenyl)cyclopropylamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1R,2S)-2-(2-methoxyphenyl)cyclopropylamine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1R,2S)-2-(2-methoxyphenyl)cyclopropylamine

There total 15 articles about (1R,2S)-2-(2-methoxyphenyl)cyclopropylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1011-54-7
2-methoxycinnamic acid

: 110901-87-6,741231-40-3,748093-78-9,748730-84-9
(1R,2S)-2-(2-methoxyphenyl)cyclopropylamine

Guidance literature:: Multi-step reaction with 7 steps

1: SOCl₂ / 2 h / Ambient temperature

2: 1.) NaH / 1) toluene, 30 min; 2) toluene, overnight

3: 73 percent / Pd(OAc)2 / CH₂Cl₂ / 3 h / 0 - 5 °C

4: 1.) titanium(IV) isopropoxide, benzyl alcohol, 2.) aq. NaOH / 1) 150 deg C, 30 min; 2) THF, MeOH, 2 h

5: 1.) ethyl chloroformate, Et₃N, 2.) aq. NaN₃ / 1) -10 deg C, acetone, 2 h; 2) -10 deg C, acetone, 1 h

6: 1) toluene, 90 deg C, 3 h; 2) reflux, 16 h

7: aq. HCl / 0.33 h / 100 °C

With titanium(IV) isopropylate; hydrogenchloride; palladium diacetate; sodium hydroxide; thionyl chloride; sodium azide; chloroformic acid ethyl ester; sodium hydride; triethylamine; benzyl alcohol; In dichloromethane;

Reference yield:

: 135-02-4
ortho-anisaldehyde

: 110901-87-6,741231-40-3,748093-78-9,748730-84-9
(1R,2S)-2-(2-methoxyphenyl)cyclopropylamine

Guidance literature:: Multi-step reaction with 9 steps

3: 100 percent / Pd(OAc)2 / diethyl ether; CH₂Cl₂ / 1 h / -10 - -5 °C

4: 92 percent / NaOH / methanol

5: SOCl₂ / 0.75 h / 55 °C

6: 44 percent / Et₃N / CH₂Cl₂ / 1.) 0 deh C, 30 min, 2.) room temperature, overnight

7: 97 percent / H₂SO₄ / dioxane / 24 h / 100 °C

8: diphenylphosphoryl azide, Et₃N / 27 h / 90 °C

9: 1N HCl / 5 h / 100 °C

With hydrogenchloride; sodium hydroxide; thionyl chloride; sulfuric acid; diphenylphosphoranyl azide; triethylamine; palladium diacetate; In 1,4-dioxane; methanol; diethyl ether; dichloromethane;
DOI:10.1021/jm00396a014