1-{4-[3-(4-methanesulfonylphenyl)-7-phenyl-imidazo[1,2-b]pyridazin-6-yl]-phenyl}-cyclobutylamine

Base Information

Chemical Name:1-{4-[3-(4-methanesulfonylphenyl)-7-phenyl-imidazo[1,2-b]pyridazin-6-yl]-phenyl}-cyclobutylamine
CAS No.:1357262-70-4
Molecular Formula:C₂₉H₂₆N₄O₂S
Molecular Weight:494.617
Hs Code.:

Synonyms:1-{4-[3-(4-methanesulfonylphenyl)-7-phenyl-imidazo[1,2-b]pyridazin-6-yl]-phenyl}-cyclobutylamine

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Chemical Property of 1-{4-[3-(4-methanesulfonylphenyl)-7-phenyl-imidazo[1,2-b]pyridazin-6-yl]-phenyl}-cyclobutylamine

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Technology Process of 1-{4-[3-(4-methanesulfonylphenyl)-7-phenyl-imidazo[1,2-b]pyridazin-6-yl]-phenyl}-cyclobutylamine

There total 5 articles about 1-{4-[3-(4-methanesulfonylphenyl)-7-phenyl-imidazo[1,2-b]pyridazin-6-yl]-phenyl}-cyclobutylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1357263-13-8
(1-{4-[3-(4-methanesulfonyl-phenyl)-7-phenyl-imidazo[1,2-b]pyridazin-6-yl]-phenyl}-cyclobutyl)-carbamic acid tert.-butyl ester

: 1357262-70-4
1-{4-[3-(4-methanesulfonylphenyl)-7-phenyl-imidazo[1,2-b]pyridazin-6-yl]-phenyl}-cyclobutylamine

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 23h;

Reference yield:

: 1357263-05-8
6-chloro-7-phenyl-imidazo[1,2-b]pyridazine

: 1357262-70-4
1-{4-[3-(4-methanesulfonylphenyl)-7-phenyl-imidazo[1,2-b]pyridazin-6-yl]-phenyl}-cyclobutylamine

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane / 24 h / 90 °C / Microwave irradiation; Inert atmosphere

2: N-Bromosuccinimide / chloroform / 1 h / Reflux

3: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; 1,4-dioxane / 18 h / 105 °C

4: hydrogenchloride / 1,4-dioxane / 23 h / 20 °C

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-Bromosuccinimide; sodium carbonate; In 1,4-dioxane; 1,2-dimethoxyethane; chloroform; water;

Reference yield:

: 1032528-06-5
{1-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-cyclobutyl}-carbamic acid tert.-butyl ester

: 1357262-70-4
1-{4-[3-(4-methanesulfonylphenyl)-7-phenyl-imidazo[1,2-b]pyridazin-6-yl]-phenyl}-cyclobutylamine

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane / 24 h / 90 °C / Microwave irradiation; Inert atmosphere

2: N-Bromosuccinimide / chloroform / 1 h / Reflux

3: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; 1,4-dioxane / 18 h / 105 °C

4: hydrogenchloride / 1,4-dioxane / 23 h / 20 °C

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-Bromosuccinimide; sodium carbonate; In 1,4-dioxane; 1,2-dimethoxyethane; chloroform; water;