4'-((2-methyl-7H-pyrrolo<2,3-d>pyrimidin-4-yl)thio)-2-biphenylcarbonitrile

Base Information

Chemical Name:4'-((2-methyl-7H-pyrrolo<2,3-d>pyrimidin-4-yl)thio)-2-biphenylcarbonitrile
CAS No.:1026074-39-4
Molecular Formula:C₂₀H₁₄N₄S
Molecular Weight:342.424
Hs Code.:

Synonyms:4'-((2-methyl-7H-pyrrolo<2,3-d>pyrimidin-4-yl)thio)-2-biphenylcarbonitrile

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Chemical Property of 4'-((2-methyl-7H-pyrrolo<2,3-d>pyrimidin-4-yl)thio)-2-biphenylcarbonitrile

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Technology Process of 4'-((2-methyl-7H-pyrrolo<2,3-d>pyrimidin-4-yl)thio)-2-biphenylcarbonitrile

There total 5 articles about 4'-((2-methyl-7H-pyrrolo<2,3-d>pyrimidin-4-yl)thio)-2-biphenylcarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 71149-52-5
4-chloro-2-methyl-7H-pyrrolo[2,3-d]pyrimidine

: 171879-77-9
Trifluoro-acetic acid 2'-cyano-biphenyl-4-ylsulfanylmethyl ester

: 1026074-39-4
4'-((2-methyl-7H-pyrrolo<2,3-d>pyrimidin-4-yl)thio)-2-biphenylcarbonitrile

Guidance literature:: With triethylamine; In methanol; for 1h; Heating;
DOI:10.1021/jm00023a006

Reference yield:

: 104-95-0
(4-bromophenyl)thioanisole

: 1026074-39-4
4'-((2-methyl-7H-pyrrolo<2,3-d>pyrimidin-4-yl)thio)-2-biphenylcarbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) n-butyllithium, 2.) triisopropyl borate, 3.) aq. HCl, 4.) tetrakis(triphenylphosphine)palladium, Na₂CO₃

2: 83 percent / 3-chloroperoxybenzoic acid / CH₂Cl₂ / 2.42 h / -78 °C

3: 0.5 h / Heating

4: 34 percent / Et₃N / methanol / 1 h / Heating

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; Triisopropyl borate; sodium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; In methanol; dichloromethane;
DOI:10.1021/jm00023a006

Reference yield:

: 2042-37-7
o-cyanobromobenzene

: 1026074-39-4
4'-((2-methyl-7H-pyrrolo<2,3-d>pyrimidin-4-yl)thio)-2-biphenylcarbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) n-butyllithium, 2.) triisopropyl borate, 3.) aq. HCl, 4.) tetrakis(triphenylphosphine)palladium, Na₂CO₃

2: 83 percent / 3-chloroperoxybenzoic acid / CH₂Cl₂ / 2.42 h / -78 °C

3: 0.5 h / Heating

4: 34 percent / Et₃N / methanol / 1 h / Heating

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; Triisopropyl borate; sodium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; In methanol; dichloromethane;
DOI:10.1021/jm00023a006