(25R)-1α,3β,25-trihydroxy-5,7,22-cholestatrien-26-oic acid 4-phenyl-1,2,4-triazoline-3,5-dione adduct

Base Information

Chemical Name:(25R)-1α,3β,25-trihydroxy-5,7,22-cholestatrien-26-oic acid 4-phenyl-1,2,4-triazoline-3,5-dione adduct
CAS No.:137649-18-4
Molecular Formula:C₃₅H₄₅N₃O₇
Molecular Weight:619.758
Hs Code.:

Synonyms:(25R)-1α,3β,25-trihydroxy-5,7,22-cholestatrien-26-oic acid 4-phenyl-1,2,4-triazoline-3,5-dione adduct

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Chemical Property of (25R)-1α,3β,25-trihydroxy-5,7,22-cholestatrien-26-oic acid 4-phenyl-1,2,4-triazoline-3,5-dione adduct

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Technology Process of (25R)-1α,3β,25-trihydroxy-5,7,22-cholestatrien-26-oic acid 4-phenyl-1,2,4-triazoline-3,5-dione adduct

There total 2 articles about (25R)-1α,3β,25-trihydroxy-5,7,22-cholestatrien-26-oic acid 4-phenyl-1,2,4-triazoline-3,5-dione adduct which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 137649-16-2
(25R)-5,7,22-cholestatriene-1α,3β,25,26-tetrol 1,3-diacetate 4-phenyl-1,2,4-triazoline-3,5-dione adduct

: 137649-18-4
(25R)-1α,3β,25-trihydroxy-5,7,22-cholestatrien-26-oic acid 4-phenyl-1,2,4-triazoline-3,5-dione adduct

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / Et₃N, pyridine-SO₃ complex / dimethylsulfoxide; CH₂Cl₂ / 1 h / Ambient temperature

2: KOH, I₂ / 0.5 h / 0 °C

3: 5percent aq.-methanolic KOH / 0.5 h / Ambient temperature

With potassium hydroxide; iodine; sulfur trioxide pyridine complex; triethylamine; In dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jo00027a010

Reference yield:

: 137649-15-1
(25R)-5,7,22-cholestatriene-1α,3β,25,26-tetrol 1,3-diacetate 25,26-acetonide 4-phenyl-1,2,4-triazoline-3,5-dione adduct

: 137649-18-4
(25R)-1α,3β,25-trihydroxy-5,7,22-cholestatrien-26-oic acid 4-phenyl-1,2,4-triazoline-3,5-dione adduct

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / pyridinium p-toluenesulfonate / ethanol / 1 h / Heating

2: 99 percent / Et₃N, pyridine-SO₃ complex / dimethylsulfoxide; CH₂Cl₂ / 1 h / Ambient temperature

3: KOH, I₂ / 0.5 h / 0 °C

4: 5percent aq.-methanolic KOH / 0.5 h / Ambient temperature

With potassium hydroxide; iodine; sulfur trioxide pyridine complex; pyridinium p-toluenesulfonate; triethylamine; In ethanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jo00027a010