methyl N-(tert-butoxycarbonyl)-4-[({6-[(tert-butoxycarbonyl)(methyl)amino]pyridin-2-yl}methoxy)methyl]-L-phenylalaninate

Base Information

Chemical Name:methyl N-(tert-butoxycarbonyl)-4-[({6-[(tert-butoxycarbonyl)(methyl)amino]pyridin-2-yl}methoxy)methyl]-L-phenylalaninate
CAS No.:959992-66-6
Molecular Formula:C₂₈H₃₉N₃O₇
Molecular Weight:529.634
Hs Code.:

Synonyms:methyl N-(tert-butoxycarbonyl)-4-[({6-[(tert-butoxycarbonyl)(methyl)amino]pyridin-2-yl}methoxy)methyl]-L-phenylalaninate

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Chemical Property of methyl N-(tert-butoxycarbonyl)-4-[({6-[(tert-butoxycarbonyl)(methyl)amino]pyridin-2-yl}methoxy)methyl]-L-phenylalaninate

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Technology Process of methyl N-(tert-butoxycarbonyl)-4-[({6-[(tert-butoxycarbonyl)(methyl)amino]pyridin-2-yl}methoxy)methyl]-L-phenylalaninate

There total 2 articles about methyl N-(tert-butoxycarbonyl)-4-[({6-[(tert-butoxycarbonyl)(methyl)amino]pyridin-2-yl}methoxy)methyl]-L-phenylalaninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 945245-48-7
N-tert-butyloxycarbonyl-L-(p-bromomethyl)phenylalanine methyl ester

: 959992-66-6
methyl N-(tert-butoxycarbonyl)-4-[({6-[(tert-butoxycarbonyl)(methyl)amino]pyridin-2-yl}methoxy)methyl]-L-phenylalaninate

Guidance literature:: tert-butyl [6-(hydroxymethyl)pyridin-2-yl]methylcarbamate; With sodium hydride; In N,N-dimethyl acetamide; at 0 - 20 ℃; for 0.25h;

N-tert-butyloxycarbonyl-L-(p-bromomethyl)phenylalanine methyl ester; In N,N-dimethyl acetamide;

Reference yield:

: 216774-50-4
N-tert-butyloxycarbonyl-(p-hydroxymethyl)-L-phenylalanine methyl ester

: 959992-66-6
methyl N-(tert-butoxycarbonyl)-4-[({6-[(tert-butoxycarbonyl)(methyl)amino]pyridin-2-yl}methoxy)methyl]-L-phenylalaninate

Guidance literature:: Multi-step reaction with 2 steps

1: carbon tetrabromide; triphenylphosphine / tetrahydrofuran / 3 h / 20 °C

2: sodium hydride / N,N-dimethyl acetamide / 0.25 h / 0 - 20 °C

With carbon tetrabromide; sodium hydride; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl acetamide;

Reference yield: 40.0%

: 959992-66-6
methyl N-(tert-butoxycarbonyl)-4-[({6-[(tert-butoxycarbonyl)(methyl)amino]pyridin-2-yl}methoxy)methyl]-L-phenylalaninate

: 959992-65-5
methyl 4-({[6-(methylamino)pyridin-2-yl]methoxy}methyl)-L-phenylalaninate

Guidance literature:: methyl N-(tert-butoxycarbonyl)-4-[({6-[(tert-butoxycarbonyl)(methyl)amino]pyridin-2-yl}methoxy)methyl]-L-phenylalaninate; With trifluoroacetic acid; In dichloromethane; at 20 ℃;

With ammonia; In methanol; dichloromethane;