N-tert-butyloxycarbonyl-(p-hydroxymethyl)-L-phenylalanine methyl ester

Base Information

• Chemical Name: N-tert-butyloxycarbonyl-(p-hydroxymethyl)-L-phenylalanine methyl ester
• CAS No.: 216774-50-4
• Molecular Formula: C₁₆H₂₃NO₅
• Molecular Weight: 309.362
• Mol file: 216774-50-4.mol

Synonyms:N-tert-butyloxycarbonyl-(p-hydroxymethyl)-L-phenylalanine methyl ester

Chemical Property of N-tert-butyloxycarbonyl-(p-hydroxymethyl)-L-phenylalanine methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-tert-butyloxycarbonyl-(p-hydroxymethyl)-L-phenylalanine methyl ester

There total 11 articles about N-tert-butyloxycarbonyl-(p-hydroxymethyl)-L-phenylalanine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

methyl 2-(S)-((tert-butoxycarbonyl)amino)-3-(4'-formyl-phenyl)propanoate (216774-45-7) → N-tert-butyloxycarbonyl-(p-hydroxymethyl)-L-phenylalanine methyl ester (216774-50-4)

Guidance literature:

With sodium tetrahydroborate; In methanol; dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1080/00397919809458709

Reference yield: 76.0%

(S)-4-(2-((tert-butoxycarbonyl)amino)-3-methoxy-3-oxopropyl)benzoic acid (123993-33-9) → N-tert-butyloxycarbonyl-(p-hydroxymethyl)-L-phenylalanine methyl ester (216774-50-4)

Guidance literature:

With dimethylsulfide borane complex; In tetrahydrofuran; at 0 - 25 ℃; for 2h;

DOI:10.1016/S0968-0896(00)00097-3

Reference yield: 75.0%

1-methyl-1-nitrosourea (684-93-5) + N-boc-4-hydroxymethylphenylalanine (160916-46-1) → N-tert-butyloxycarbonyl-(p-hydroxymethyl)-L-phenylalanine methyl ester (216774-50-4)

Guidance literature:

1-methyl-1-nitrosourea; With sodium hydroxide; In diethyl ether; at 0 ℃; for 0.216667h;

N-boc-4-hydroxymethylphenylalanine; In tetrahydrofuran; diethyl ether; for 0.0833333h;

upstream raw materials:

methyl 2-(S)-((tert-butoxycarbonyl)amino)-3-(4'-formyl-phenyl)propanoate

diazomethane

N-boc-4-hydroxymethylphenylalanine

(S)-4-(2-((tert-butoxycarbonyl)amino)-3-methoxy-3-oxopropyl)benzoic acid

Downstream raw materials:

methyl 2-(S)-((tert-butoxycarbonyl)amino)-3-(4'-formyl-phenyl)propanoate

N-tert-butyloxycarbonyl-L-(p-bromomethyl)phenylalanine methyl ester

(S)-4-(2-((tert-butoxycarbonyl)amino)-3-methoxy-3-oxopropyl)benzoic acid