1-[3-[2-chloro-4-(4-chlorophenoxy)phenyl]-2-(1-chlorocyclopropyl)-2-methoxy-1-methyl-propyl]-1,2,4-triazole

Base Information

Chemical Name:1-[3-[2-chloro-4-(4-chlorophenoxy)phenyl]-2-(1-chlorocyclopropyl)-2-methoxy-1-methyl-propyl]-1,2,4-triazole
CAS No.:1614262-36-0
Molecular Formula:C₂₂H₂₂Cl₃N₃O₂
Molecular Weight:466.795
Hs Code.:

Synonyms:1-[3-[2-chloro-4-(4-chlorophenoxy)phenyl]-2-(1-chlorocyclopropyl)-2-methoxy-1-methyl-propyl]-1,2,4-triazole

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Chemical Property of 1-[3-[2-chloro-4-(4-chlorophenoxy)phenyl]-2-(1-chlorocyclopropyl)-2-methoxy-1-methyl-propyl]-1,2,4-triazole

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Technology Process of 1-[3-[2-chloro-4-(4-chlorophenoxy)phenyl]-2-(1-chlorocyclopropyl)-2-methoxy-1-methyl-propyl]-1,2,4-triazole

There total 8 articles about 1-[3-[2-chloro-4-(4-chlorophenoxy)phenyl]-2-(1-chlorocyclopropyl)-2-methoxy-1-methyl-propyl]-1,2,4-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1614262-38-2
1-[2-chloro-4-(4-chlorophenoxy)phenyl]-2-(1-chlorocyclopropyl)-3-(1,2,4-triazol-1-yl)butan-2-ol

: 74-88-4
methyl iodide

: 1614262-36-0
1-[3-[2-chloro-4-(4-chlorophenoxy)phenyl]-2-(1-chlorocyclopropyl)-2-methoxy-1-methyl-propyl]-1,2,4-triazole

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 2h;

Reference yield:

: 1614262-45-1
2-(2-chloro-4-(4-chlorophenoxy)phenyl)acetaldehyde

: 1614262-36-0
1-[3-[2-chloro-4-(4-chlorophenoxy)phenyl]-2-(1-chlorocyclopropyl)-2-methoxy-1-methyl-propyl]-1,2,4-triazole

Guidance literature:: Multi-step reaction with 7 steps

1: 2-methyl-but-2-ene / tetrahydrofuran; tert-butyl alcohol; water / 1 h / 0 °C

2: dmap / tetrahydrofuran; tert-butyl alcohol / Reflux

3: lithium hexamethyldisilazane / tetrahydrofuran / 4.33 h / 0 °C

4: trifluoroacetic acid / dichloromethane / 20 °C

5: n-butyllithium / tetrahydrofuran / -78 - 20 °C

6: 1,8-diazabicyclo[5.4.0]undec-7-ene / 2-methyl-propan-1-ol / 5 h / 180 °C / Microwave irradiation

7: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 0 °C

With dmap; n-butyllithium; 2-methyl-but-2-ene; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; 2-methyl-propan-1-ol; water; N,N-dimethyl-formamide; mineral oil; tert-butyl alcohol;

Reference yield:

: 1614262-46-2
2-(2-chloro-4-(4-chlorophenoxy)phenyl)acetic acid

: 1614262-36-0
1-[3-[2-chloro-4-(4-chlorophenoxy)phenyl]-2-(1-chlorocyclopropyl)-2-methoxy-1-methyl-propyl]-1,2,4-triazole

Guidance literature:: Multi-step reaction with 6 steps

1: dmap / tetrahydrofuran; tert-butyl alcohol / Reflux

2: lithium hexamethyldisilazane / tetrahydrofuran / 4.33 h / 0 °C

3: trifluoroacetic acid / dichloromethane / 20 °C

4: n-butyllithium / tetrahydrofuran / -78 - 20 °C

5: 1,8-diazabicyclo[5.4.0]undec-7-ene / 2-methyl-propan-1-ol / 5 h / 180 °C / Microwave irradiation

6: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 0 °C

With dmap; n-butyllithium; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; 2-methyl-propan-1-ol; N,N-dimethyl-formamide; mineral oil; tert-butyl alcohol;