1-({N-(tert-butyloxycarbonyl)-4-[bis(2-chloroethyl)amino]-L-phenylalanyl}-amino)-3-(dimethylamino)propane

Base Information

• Chemical Name: 1-({N-(tert-butyloxycarbonyl)-4-[bis(2-chloroethyl)amino]-L-phenylalanyl}-amino)-3-(dimethylamino)propane
• CAS No.: 316147-12-3
• Molecular Formula: C₂₃H₃₈Cl₂N₄O₃
• Molecular Weight: 489.486
• Mol file: 316147-12-3.mol

Synonyms:1-({N-(tert-butyloxycarbonyl)-4-[bis(2-chloroethyl)amino]-L-phenylalanyl}-amino)-3-(dimethylamino)propane

Chemical Property of 1-({N-(tert-butyloxycarbonyl)-4-[bis(2-chloroethyl)amino]-L-phenylalanyl}-amino)-3-(dimethylamino)propane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-({N-(tert-butyloxycarbonyl)-4-[bis(2-chloroethyl)amino]-L-phenylalanyl}-amino)-3-(dimethylamino)propane

There total 5 articles about 1-({N-(tert-butyloxycarbonyl)-4-[bis(2-chloroethyl)amino]-L-phenylalanyl}-amino)-3-(dimethylamino)propane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + 1-amino-3-(dimethylamino)propane (109-55-7) + melphalan hydrochloride (3223-07-2,4213-32-5) → 1-({N-(tert-butyloxycarbonyl)-4-[bis(2-chloroethyl)amino]-L-phenylalanyl}-amino)-3-(dimethylamino)propane (316147-12-3)

Guidance literature:

di-tert-butyl dicarbonate; melphalan hydrochloride; With triethylamine; In methanol; at 20 - 40 ℃; for 0.5h;

With hydrogenchloride; In water; pH=2;

1-amino-3-(dimethylamino)propane; With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 5h;

Reference yield:

N-((tert-butoxy)carbonyl)-4-(bis(2-chloroethyl)amino)-L-phenylalanine (79145-92-9) + 1-amino-3-(dimethylamino)propane (109-55-7) → 1-({N-(tert-butyloxycarbonyl)-4-[bis(2-chloroethyl)amino]-L-phenylalanyl}-amino)-3-(dimethylamino)propane (316147-12-3)

Guidance literature:

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 5h;

DOI:10.1021/jm010926x

Reference yield:

tert-butyldicarbonate (34619-03-9) → 1-({N-(tert-butyloxycarbonyl)-4-[bis(2-chloroethyl)amino]-L-phenylalanyl}-amino)-3-(dimethylamino)propane (316147-12-3)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / methanol / 0.5 h / 20 °C

2: 871 mg / DCC; HOBT / CH₂Cl₂ / 5 h / 20 °C

With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In methanol; dichloromethane;

DOI:10.1021/jm010926x

upstream raw materials:

N-((tert-butoxy)carbonyl)-4-(bis(2-chloroethyl)amino)-L-phenylalanine

1-amino-3-(dimethylamino)propane

tert-butyldicarbonate

di-tert-butyl dicarbonate