4-(1-hexynyl)-4-hydroxy-2-isopropoxy-3-phenyl-2-cyclobutenone ethylene acetal

Base Information

Chemical Name:4-(1-hexynyl)-4-hydroxy-2-isopropoxy-3-phenyl-2-cyclobutenone ethylene acetal
CAS No.:128242-58-0
Molecular Formula:C₂₁H₂₆O₄
Molecular Weight:342.435
Hs Code.:

Synonyms:4-(1-hexynyl)-4-hydroxy-2-isopropoxy-3-phenyl-2-cyclobutenone ethylene acetal

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Chemical Property of 4-(1-hexynyl)-4-hydroxy-2-isopropoxy-3-phenyl-2-cyclobutenone ethylene acetal

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Technology Process of 4-(1-hexynyl)-4-hydroxy-2-isopropoxy-3-phenyl-2-cyclobutenone ethylene acetal

There total 3 articles about 4-(1-hexynyl)-4-hydroxy-2-isopropoxy-3-phenyl-2-cyclobutenone ethylene acetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

: 17689-03-1
1-hexynyllithium

: 128242-44-4
3-(1-methylethoxy)-4-phenyl-3-cyclobutene-1,2-dione 2-ethylene acetal

: 128242-74-0
3-(1-hexynyl)-4-phenyl-3-cyclobutene-1,2-dione 2-(ethylene acetal)

: 128242-58-0
4-(1-hexynyl)-4-hydroxy-2-isopropoxy-3-phenyl-2-cyclobutenone ethylene acetal

Guidance literature:: In diethyl ether; for 0.333333h; Ambient temperature;
DOI:10.1021/jo00306a011

Reference yield:

: 114094-64-3
2,3-bis(1-methylethoxy)-4-hydroxy-4-phenylcyclobut-2-en-1-one

: 128242-58-0
4-(1-hexynyl)-4-hydroxy-2-isopropoxy-3-phenyl-2-cyclobutenone ethylene acetal

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / NEt₃ / diethyl ether / 12 h

2: 80 percent / trimethylsilyl triflate / tetrahydrofuran / 6 h

3: 74 percent / diethyl ether / 0.33 h / Ambient temperature

With triethylamine; trimethylsilyl trifluoromethanesulfonate; In tetrahydrofuran; diethyl ether;
DOI:10.1021/jo00306a011

Reference yield:

: 128242-38-6
2,3-diisopropoxy-4-phenyl-4-(trimethylsiloxy)-2-cyclobuten-1-one

: 128242-58-0
4-(1-hexynyl)-4-hydroxy-2-isopropoxy-3-phenyl-2-cyclobutenone ethylene acetal

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / trimethylsilyl triflate / tetrahydrofuran / 6 h

2: 74 percent / diethyl ether / 0.33 h / Ambient temperature

trimethylsilyl trifluoromethanesulfonate; In tetrahydrofuran; diethyl ether;
DOI:10.1021/jo00306a011