4-Methyl-benzenesulfinic acid 1-((R)-1-benzyl-aziridin-2-yl)-meth-(E)-ylideneamide

Base Information

• Chemical Name: 4-Methyl-benzenesulfinic acid 1-((R)-1-benzyl-aziridin-2-yl)-meth-(E)-ylideneamide
• CAS No.: 429694-44-0
• Molecular Formula: C₁₇H₁₈N₂OS
• Molecular Weight: 298.409

Synonyms:4-Methyl-benzenesulfinic acid 1-((R)-1-benzyl-aziridin-2-yl)-meth-(E)-ylideneamide

Chemical Property of 4-Methyl-benzenesulfinic acid 1-((R)-1-benzyl-aziridin-2-yl)-meth-(E)-ylideneamide

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Technology Process of 4-Methyl-benzenesulfinic acid 1-((R)-1-benzyl-aziridin-2-yl)-meth-(E)-ylideneamide

There total 1 articles about 4-Methyl-benzenesulfinic acid 1-((R)-1-benzyl-aziridin-2-yl)-meth-(E)-ylideneamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

1-benzyl-2-aziridine carboxaldehyde (30005-72-2) + (S)-p-toluenesulfinimide (188447-91-8) → 4-Methyl-benzenesulfinic acid 1-((S)-1-benzyl-aziridin-2-yl)-meth-(E)-ylideneamide (463310-66-9) + 4-Methyl-benzenesulfinic acid 1-((R)-1-benzyl-aziridin-2-yl)-meth-(E)-ylideneamide (429694-44-0)

Guidance literature:

With titanium(IV) tetraethanolate; In dichloromethane; for 10h; Heating;

DOI:10.1021/jo016106+

Reference yield: 84.0%

trimethylsilyl cyanide (7677-24-9) + 4-Methyl-benzenesulfinic acid 1-((R)-1-benzyl-aziridin-2-yl)-meth-(E)-ylideneamide (429694-44-0) → (2R,SS,αR)-α-(p-toluenesulfinylamino)-α-(1-benzylaziridin-2-yl)acetonitrile

Guidance literature:

With cesium fluoride; In tetrahydrofuran; at -50 ℃;

DOI:10.1021/jo034477f

Reference yield: 83.0%

sodium dimethyl phosphonate (17201-06-8) + 4-Methyl-benzenesulfinic acid 1-((R)-1-benzyl-aziridin-2-yl)-meth-(E)-ylideneamide (429694-44-0) → [(R)-((R)-1-Benzyl-aziridin-2-yl)-((S)-toluene-4-sulfinylamino)-methyl]-phosphonic acid dimethyl ester

Guidance literature:

With zinc dibromide; In tetrahydrofuran; at -78 ℃;

DOI:10.1021/jo016106+

upstream raw materials:

1-benzyl-2-aziridine carboxaldehyde

(S)-p-toluenesulfinimide

Downstream raw materials:

C₂₅H₃₉N₄O₂PS

4-Methyl-benzenesulfinic acid [(1R,2S)-2-benzylamino-3-(4-chloro-phenylsulfanyl)-1-cyano-propyl]-amide

C₃₁H₄₄ClN₄O₂PS₂

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