N-{trans-4-[4-(3-{(1S)-1-[2-Chloro-6-(difluoromethoxy)-3-fluorophenyl]ethyl}-1H-pyrrolo[2,3-b]pyridin-5-yl)-5-methyl-1H-pyrazol-1-yl]cyclohexyl}-N-methylglycine

Base Information

Chemical Name:N-{trans-4-[4-(3-{(1S)-1-[2-Chloro-6-(difluoromethoxy)-3-fluorophenyl]ethyl}-1H-pyrrolo[2,3-b]pyridin-5-yl)-5-methyl-1H-pyrazol-1-yl]cyclohexyl}-N-methylglycine
CAS No.:1350324-63-8
Molecular Formula:C₂₉H₃₁ClF₃N₅O₃
Molecular Weight:590.045
Hs Code.:

N-{trans-4-[4-(3-{(1S)-1-[2-Chloro-6-(difluoromethoxy)-3-fluorophenyl]ethyl}-1H-pyrrolo[2,3-b]pyridin-5-yl)-5-methyl-1H-pyrazol-1-yl]cyclohexyl}-N-methylglycine

Synonyms:N-{trans-4-[4-(3-{(1S)-1-[2-Chloro-6-(difluoromethoxy)-3-fluorophenyl]ethyl}-1H-pyrrolo[2,3-b]pyridin-5-yl)-5-methyl-1H-pyrazol-1-yl]cyclohexyl}-N-methylglycine

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Chemical Property of N-{trans-4-[4-(3-{(1S)-1-[2-Chloro-6-(difluoromethoxy)-3-fluorophenyl]ethyl}-1H-pyrrolo[2,3-b]pyridin-5-yl)-5-methyl-1H-pyrazol-1-yl]cyclohexyl}-N-methylglycine

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Technology Process of N-{trans-4-[4-(3-{(1S)-1-[2-Chloro-6-(difluoromethoxy)-3-fluorophenyl]ethyl}-1H-pyrrolo[2,3-b]pyridin-5-yl)-5-methyl-1H-pyrazol-1-yl]cyclohexyl}-N-methylglycine

There total 16 articles about N-{trans-4-[4-(3-{(1S)-1-[2-Chloro-6-(difluoromethoxy)-3-fluorophenyl]ethyl}-1H-pyrrolo[2,3-b]pyridin-5-yl)-5-methyl-1H-pyrazol-1-yl]cyclohexyl}-N-methylglycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1350324-62-7
4-[4-(3-{(1S)-1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl]ethyl}-1H-pyrrolo[2,3-b]pyridin-5-yl)-5-methyl-1H-pyrazol-1-yl]cyclohexanone

: 13515-93-0
N-methylglycine methyl ester hydrochloride

: 1350324-63-8
N-{trans-4-[4-(3-{(1S)-1-[2-Chloro-6-(difluoromethoxy)-3-fluorophenyl]ethyl}-1H-pyrrolo[2,3-b]pyridin-5-yl)-5-methyl-1H-pyrazol-1-yl]cyclohexyl}-N-methylglycine

: 1350324-64-9
N-{cis-4-[4-(3-{(1S)-1-[2-Chloro-6-(difluoromethoxy)-3-fluorophenyl]ethyl}-1H-pyrrolo[2,3-b]pyridin-5-yl)-5-methyl-1H-pyrazol-1-yl]cyclohexyl}-N-methylglycine

Guidance literature:: 4-[4-(3-{(1S)-1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl]ethyl}-1H-pyrrolo[2,3-b]pyridin-5-yl)-5-methyl-1H-pyrazol-1-yl]cyclohexanone; N-methylglycine methyl ester hydrochloride; With sodium tris(acetoxy)borohydride; triethylamine; In 1,2-dichloro-ethane; at 50 ℃;

With lithium hydroxide monohydrate; In methanol; at 50 ℃; for 3h;

Reference yield:

: 1350324-11-6
tert-butyl 5-bromo-3-{(1S)-1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl]-ethyl}-1H-pyrrolo[2,3-b]pyridine-1-carboxylate

: 1350324-63-8
N-{trans-4-[4-(3-{(1S)-1-[2-Chloro-6-(difluoromethoxy)-3-fluorophenyl]ethyl}-1H-pyrrolo[2,3-b]pyridin-5-yl)-5-methyl-1H-pyrazol-1-yl]cyclohexyl}-N-methylglycine

: 1350324-64-9
N-{cis-4-[4-(3-{(1S)-1-[2-Chloro-6-(difluoromethoxy)-3-fluorophenyl]ethyl}-1H-pyrrolo[2,3-b]pyridin-5-yl)-5-methyl-1H-pyrazol-1-yl]cyclohexyl}-N-methylglycine

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 2 h / 95 °C

2.1: hydrogenchloride; water / 1,4-dioxane / 45 °C

3.1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 0.08 h / 20 °C

4.1: triethylamine; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 50 °C

4.2: 3 h / 50 °C

With hydrogenchloride; water; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; potassium carbonate; Dess-Martin periodane; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; water; 1,2-dichloro-ethane;

Reference yield:

: 1350324-14-9
tert-butyl 5-bromo-3-[(1S)-1-{6-[(tert-butoxycarbonyl)oxy]-2-chloro-3-fluorophenyl}ethyl]-1H-pyrrolo[2,3-b]pyridine-1-carboxylate

: 1350324-63-8
N-{trans-4-[4-(3-{(1S)-1-[2-Chloro-6-(difluoromethoxy)-3-fluorophenyl]ethyl}-1H-pyrrolo[2,3-b]pyridin-5-yl)-5-methyl-1H-pyrazol-1-yl]cyclohexyl}-N-methylglycine

: 1350324-64-9
N-{cis-4-[4-(3-{(1S)-1-[2-Chloro-6-(difluoromethoxy)-3-fluorophenyl]ethyl}-1H-pyrrolo[2,3-b]pyridin-5-yl)-5-methyl-1H-pyrazol-1-yl]cyclohexyl}-N-methylglycine

Guidance literature:: Multi-step reaction with 6 steps

1.1: piperidine / dichloromethane / 16 h / 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 70 °C / sealed tube

3.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 2 h / 95 °C

4.1: hydrogenchloride; water / 1,4-dioxane / 45 °C

5.1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 0.08 h / 20 °C

6.1: triethylamine; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 50 °C

6.2: 3 h / 50 °C

With piperidine; hydrogenchloride; water; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; potassium carbonate; Dess-Martin periodane; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;