(2-Methoxy-2-oxoethyl)-methylazanium;chloride

Base Information

• Chemical Name: (2-Methoxy-2-oxoethyl)-methylazanium;chloride
• CAS No.: 13515-93-0
• Molecular Formula: C4H9NO2^.HCl
• Molecular Weight: 139.582
• Hs Code.: 29224999
• Mol file: 13515-93-0.mol

Synonyms:(2-methoxy-2-oxoethyl)-methylazanium;chloride;AKOS023093311

Chemical Property of (2-Methoxy-2-oxoethyl)-methylazanium;chloride

Chemical Property:

• Appearance/Colour: White to beige crystals or crystalline powder
• Vapor Pressure: 16.3mmHg at 25°C
• Melting Point: 150 °C(lit.)
• Refractive Index: 1.4
• Boiling Point: 118.9 °C at 760mmHg
• Flash Point: 25.7 °C
• PSA: 38.33000
• Density: 0.964g/cm3
• LogP: 0.57170
• Storage Temp.: Store at RT.
• Sensitive.: Hygroscopic
• Water Solubility.: Soluble in water.
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 139.0400063
• Heavy Atom Count: 8
• Complexity: 62.7

Purity/Quality:

99.9% ^*data from raw suppliers

Sarcosine methyl ester hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn,O,Xi
• Hazard Codes: Xn,O,Xi
• Statements: 22-37/38-41-36/37/38
• Safety Statements: 26-39-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C[NH2+]CC(=O)OC.[Cl-]
• Uses: It can react with formic acid to get N-formyl-N-methyl-glycine methyl ester in the presence of HCO2Na at ambient temperature.

Technology Process of (2-Methoxy-2-oxoethyl)-methylazanium;chloride

There total 6 articles about (2-Methoxy-2-oxoethyl)-methylazanium;chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl 2-((tert-butoxycarbonyl)(methyl)amino)acetate (42492-57-9) → N-methylglycine methyl ester hydrochloride (13515-93-0)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 0 - 20 ℃; for 1h;

DOI:10.1016/j.tet.2012.06.056

Reference yield: 100.0%

methanol (67-56-1) + sarcosine (107-97-1,25951-24-0) → N-methylglycine methyl ester hydrochloride (13515-93-0)

Guidance literature:

With thionyl chloride; for 6.5h; Cooling; Reflux; Inert atmosphere;

DOI:10.1055/s-0036-1588324

Reference yield: 92.0%

methanol (67-56-1) + sarcosine → N-methylglycine methyl ester hydrochloride (13515-93-0)

Guidance literature:

With thionyl chloride; at 0 ℃; for 3.5h; Reflux;

DOI:10.3762/bjoc.8.122

upstream raw materials:

methanol

sarcosine

Methylamino-acetyl chloride

methyl iodide

Downstream raw materials:

methyl N-formyl-N-methylglycinate

N-methyl-N-(2,4,6-trinitrophenyl)glycine methyl ester

N-(2-Hydroxybenzyl)sarcosine methyl ester

N-(2-acetoxybenzyl)sarcosine methyl ester

Refernces

Efficient solid-phase synthesis of highly functionalized 1,4-benzodiazepin-5-one derivatives and related compounds by intramolecular aza-wittig reactions

10.1002/chem.200401112

The research focuses on the efficient solid-phase synthesis of highly functionalized 1,4-benzodiazepin-5-one derivatives and related compounds through intramolecular aza-Wittig reactions. The study utilizes the T1 triazene linker to yield 1,4-benzodiazepin-5-one, starting from various substituted triazene resins. Reactants include anthranilic acids, benzylamine resin, sarcosine methyl ester hydrochloride, and trimethylsilylazide, among others. The synthesis involves diazotation, coupling, and intramolecular cyclization steps, with polymer-supported triphenylphosphine playing a crucial role in the aza-Wittig reaction. Analyses used to characterize the compounds include 1H and 13C NMR, IR spectroscopy, mass spectrometry (EI-HRMS), gas chromatography, and elemental analysis, which confirm the structure and purity of the synthesized benzodiazepine derivatives.