trans-α-Methyl-β-phenylthioacrylic acid

Base Information

• Chemical Name: trans-α-Methyl-β-phenylthioacrylic acid
• CAS No.: 77199-25-8
• Molecular Formula: C₁₀H₁₀O₂S
• Molecular Weight: 194.254
• Mol file: 77199-25-8.mol

Synonyms:trans-α-Methyl-β-phenylthioacrylic acid

Chemical Property of trans-α-Methyl-β-phenylthioacrylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trans-α-Methyl-β-phenylthioacrylic acid

There total 2 articles about trans-α-Methyl-β-phenylthioacrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

isocyanate de chlorosulfonyle (1189-71-5) + 1-(phenylthio)-1-propene (22103-05-5) → trans-α-Methyl-β-phenylthioacrylic acid (77199-25-8)

Guidance literature:

With diethyl ether; at -50 ℃; anschliessendes Behandeln mit Wasser;

DOI:10.1248/cpb.21.1090

Reference yield:

→ trans-α-Methyl-β-phenylthioacrylic acid (77199-25-8)

Guidance literature:

Reference yield:

trans-α-Methyl-β-phenylthioacrylic acid (77199-25-8) + aniline (62-53-3) → (E)-2-methyl-N-phenyl-3-(phenylthio)-2-propenamide (99293-59-1)

Guidance literature:

trans-α-Methyl-β-phenylthioacrylic acid; With thionyl chloride; In toluene; for 1h; Reflux;

aniline; In ethyl acetate; at 20 ℃; Cooling with ice;

upstream raw materials:

isocyanate de chlorosulfonyle

1-(phenylthio)-1-propene

Downstream raw materials:

3-Methyl-4-phenylsulfanyl-5,6-dihydro-pyran-2-one

3-Methyl-4-phenylsulfanyl-1-oxa-spiro[4.5]dec-3-en-2-one

5-Hydroxy-3,5-dimethyl-4-phenylsulfanyl-5H-furan-2-one

3-Methyl-4-phenylsulfanyl-1-oxa-spiro[4.6]undec-3-en-2-one

Refernces

• 1、 Hirai,Matsuda,Kishida. "Syntheses of 2 azetidinone (β lactam) ring by chlorosulfonyl isocyanate (CSI)". . p. 1090 - 1095. Retrieved 2007/10/08.