(3S,5R,6S,8S)-3-(3-amino-2,2-dimethyl-3-oxopropylcarbamoyl)-6-azido-8-(4-methoxy-3-(methoxypropoxy)-benzyl)-2,9-dimethyldecan-5-yl methanesulfonate

Base Information

Chemical Name:(3S,5R,6S,8S)-3-(3-amino-2,2-dimethyl-3-oxopropylcarbamoyl)-6-azido-8-(4-methoxy-3-(methoxypropoxy)-benzyl)-2,9-dimethyldecan-5-yl methanesulfonate
CAS No.:1607844-95-0
Molecular Formula:C₃₁H₅₃N₅O₈S
Molecular Weight:655.857
Hs Code.:

(3S,5R,6S,8S)-3-(3-amino-2,2-dimethyl-3-oxopropylcarbamoyl)-6-azido-8-(4-methoxy-3-(methoxypropoxy)-benzyl)-2,9-dimethyldecan-5-yl methanesulfonate

Synonyms:(3S,5R,6S,8S)-3-(3-amino-2,2-dimethyl-3-oxopropylcarbamoyl)-6-azido-8-(4-methoxy-3-(methoxypropoxy)-benzyl)-2,9-dimethyldecan-5-yl methanesulfonate

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Chemical Property of (3S,5R,6S,8S)-3-(3-amino-2,2-dimethyl-3-oxopropylcarbamoyl)-6-azido-8-(4-methoxy-3-(methoxypropoxy)-benzyl)-2,9-dimethyldecan-5-yl methanesulfonate

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Technology Process of (3S,5R,6S,8S)-3-(3-amino-2,2-dimethyl-3-oxopropylcarbamoyl)-6-azido-8-(4-methoxy-3-(methoxypropoxy)-benzyl)-2,9-dimethyldecan-5-yl methanesulfonate

There total 9 articles about (3S,5R,6S,8S)-3-(3-amino-2,2-dimethyl-3-oxopropylcarbamoyl)-6-azido-8-(4-methoxy-3-(methoxypropoxy)-benzyl)-2,9-dimethyldecan-5-yl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1607844-94-9
(2S,4R,5S,7S)-N-(3-amino-2,2-dimethyl-3-oxopropyl)-5-azido-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(methoxypropoxy)benzyl)-8-methylnonanamide

: 124-63-0
methanesulfonyl chloride

: 1607844-95-0
(3S,5R,6S,8S)-3-(3-amino-2,2-dimethyl-3-oxopropylcarbamoyl)-6-azido-8-(4-methoxy-3-(methoxypropoxy)-benzyl)-2,9-dimethyldecan-5-yl methanesulfonate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 0.333333h;
DOI:10.5012/bkcs.2013.34.12.3777

Reference yield:

: 1607844-98-3
C₁₄H₁₈O₄

: 1607844-95-0
(3S,5R,6S,8S)-3-(3-amino-2,2-dimethyl-3-oxopropylcarbamoyl)-6-azido-8-(4-methoxy-3-(methoxypropoxy)-benzyl)-2,9-dimethyldecan-5-yl methanesulfonate

Guidance literature:: Multi-step reaction with 7 steps

1.1: palladium on activated charcoal; hydrogen / ethanol

2.1: tert.-butyl lithium / tetrahydrofuran; pentane / 2 h / -78 °C

2.2: 4 h / -78 °C

3.1: palladium on activated charcoal; hydrogen / methanol / 60 h / 2844.39 Torr

4.1: triethylamine / dichloromethane / 1.17 h / 20 °C

5.1: sodium azide / N,N-dimethyl-formamide / 25 h / 80 °C

6.1: propionic acid / 2 h / 110 °C

7.1: triethylamine / dichloromethane / 0.33 h / 20 °C

With sodium azide; palladium on activated charcoal; hydrogen; tert.-butyl lithium; propionic acid; triethylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; pentane;
DOI:10.5012/bkcs.2013.34.12.3777

Reference yield:

: C₂₁H₃₄O₆

: 1607844-95-0
(3S,5R,6S,8S)-3-(3-amino-2,2-dimethyl-3-oxopropylcarbamoyl)-6-azido-8-(4-methoxy-3-(methoxypropoxy)-benzyl)-2,9-dimethyldecan-5-yl methanesulfonate

Guidance literature:: Multi-step reaction with 8 steps

1.1: trifluoroacetic acid / ethanol

2.1: palladium on activated charcoal; hydrogen / ethanol

3.1: tert.-butyl lithium / tetrahydrofuran; pentane / 2 h / -78 °C

3.2: 4 h / -78 °C

4.1: palladium on activated charcoal; hydrogen / methanol / 60 h / 2844.39 Torr

5.1: triethylamine / dichloromethane / 1.17 h / 20 °C

6.1: sodium azide / N,N-dimethyl-formamide / 25 h / 80 °C

7.1: propionic acid / 2 h / 110 °C

8.1: triethylamine / dichloromethane / 0.33 h / 20 °C

With sodium azide; palladium on activated charcoal; hydrogen; tert.-butyl lithium; propionic acid; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; pentane;
DOI:10.5012/bkcs.2013.34.12.3777