(2S,4R,5S,7S)-N-(3-amino-2,2-dimethyl-3-oxopropyl)-5-azido-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(methoxypropoxy)benzyl)-8-methylnonanamide

Base Information

Chemical Name:(2S,4R,5S,7S)-N-(3-amino-2,2-dimethyl-3-oxopropyl)-5-azido-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(methoxypropoxy)benzyl)-8-methylnonanamide
CAS No.:1607844-94-9
Molecular Formula:C₃₀H₅₁N₅O₆
Molecular Weight:577.765
Hs Code.:

Synonyms:(2S,4R,5S,7S)-N-(3-amino-2,2-dimethyl-3-oxopropyl)-5-azido-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(methoxypropoxy)benzyl)-8-methylnonanamide

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Chemical Property of (2S,4R,5S,7S)-N-(3-amino-2,2-dimethyl-3-oxopropyl)-5-azido-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(methoxypropoxy)benzyl)-8-methylnonanamide

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Technology Process of (2S,4R,5S,7S)-N-(3-amino-2,2-dimethyl-3-oxopropyl)-5-azido-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(methoxypropoxy)benzyl)-8-methylnonanamide

There total 7 articles about (2S,4R,5S,7S)-N-(3-amino-2,2-dimethyl-3-oxopropyl)-5-azido-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(methoxypropoxy)benzyl)-8-methylnonanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 324763-51-1
aminopivalinamide

: 1309922-72-2
(3S,5R)-5-((1S,3S)-1-azido-3-(4-methoxy-3-(methoxypropoxy)benzyl)-4-methylpentyl)-3-isopropyl-dihydrofuran-2(3H)-one

: 1607844-94-9
(2S,4R,5S,7S)-N-(3-amino-2,2-dimethyl-3-oxopropyl)-5-azido-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(methoxypropoxy)benzyl)-8-methylnonanamide

Guidance literature:: With propionic acid; at 110 ℃; for 2h;
DOI:10.5012/bkcs.2013.34.12.3777

Reference yield:

: C₂₁H₃₄O₆

: 1607844-94-9
(2S,4R,5S,7S)-N-(3-amino-2,2-dimethyl-3-oxopropyl)-5-azido-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(methoxypropoxy)benzyl)-8-methylnonanamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: trifluoroacetic acid / ethanol

2.1: palladium on activated charcoal; hydrogen / ethanol

3.1: tert.-butyl lithium / tetrahydrofuran; pentane / 2 h / -78 °C

3.2: 4 h / -78 °C

4.1: palladium on activated charcoal; hydrogen / methanol / 60 h / 2844.39 Torr

5.1: triethylamine / dichloromethane / 1.17 h / 20 °C

6.1: sodium azide / N,N-dimethyl-formamide / 25 h / 80 °C

7.1: propionic acid / 2 h / 110 °C

With sodium azide; palladium on activated charcoal; hydrogen; tert.-butyl lithium; propionic acid; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; pentane;
DOI:10.5012/bkcs.2013.34.12.3777

Reference yield:

: 1309922-64-2
(2R,2'R,4R,4'R)-4,4'-diisopropyl-tetrahydro-2,2'-bifuran-5,5'(2H,2'H)-dione

: 1607844-94-9
(2S,4R,5S,7S)-N-(3-amino-2,2-dimethyl-3-oxopropyl)-5-azido-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(methoxypropoxy)benzyl)-8-methylnonanamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: tert.-butyl lithium / tetrahydrofuran; pentane / 2 h / -78 °C

1.2: 4 h / -78 °C

2.1: palladium on activated charcoal; hydrogen / methanol / 60 h / 2844.39 Torr

3.1: triethylamine / dichloromethane / 1.17 h / 20 °C

4.1: sodium azide / N,N-dimethyl-formamide / 25 h / 80 °C

5.1: propionic acid / 2 h / 110 °C

With sodium azide; palladium on activated charcoal; hydrogen; tert.-butyl lithium; propionic acid; triethylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; pentane;
DOI:10.5012/bkcs.2013.34.12.3777