tert-butyl {3-nitro-5-[2-(3-oxo-1,4-diazepan-1-yl)-1,3-thiazol-5-yl]phenyl}[4-(trifluoromethyl)pyrimidin-2-yl]carbamate

Base Information

Chemical Name:tert-butyl {3-nitro-5-[2-(3-oxo-1,4-diazepan-1-yl)-1,3-thiazol-5-yl]phenyl}[4-(trifluoromethyl)pyrimidin-2-yl]carbamate
CAS No.:1312572-77-2
Molecular Formula:C₂₄H₂₄F₃N₇O₅S
Molecular Weight:579.56
Hs Code.:

Synonyms:tert-butyl {3-nitro-5-[2-(3-oxo-1,4-diazepan-1-yl)-1,3-thiazol-5-yl]phenyl}[4-(trifluoromethyl)pyrimidin-2-yl]carbamate

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Chemical Property of tert-butyl {3-nitro-5-[2-(3-oxo-1,4-diazepan-1-yl)-1,3-thiazol-5-yl]phenyl}[4-(trifluoromethyl)pyrimidin-2-yl]carbamate

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Technology Process of tert-butyl {3-nitro-5-[2-(3-oxo-1,4-diazepan-1-yl)-1,3-thiazol-5-yl]phenyl}[4-(trifluoromethyl)pyrimidin-2-yl]carbamate

There total 7 articles about tert-butyl {3-nitro-5-[2-(3-oxo-1,4-diazepan-1-yl)-1,3-thiazol-5-yl]phenyl}[4-(trifluoromethyl)pyrimidin-2-yl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1312572-76-1
4-[5-(3-nitro-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]-1,4-diazepan-2-one

: 1312572-77-2
tert-butyl {3-nitro-5-[2-(3-oxo-1,4-diazepan-1-yl)-1,3-thiazol-5-yl]phenyl}[4-(trifluoromethyl)pyrimidin-2-yl]carbamate

Guidance literature:: With dmap; triethylamine; In tetrahydrofuran; at 20 ℃; for 60h; Inert atmosphere;

Reference yield:

: 44981-94-4
N-cyanoethyl glycine ethyl ester

: 1312572-77-2
tert-butyl {3-nitro-5-[2-(3-oxo-1,4-diazepan-1-yl)-1,3-thiazol-5-yl]phenyl}[4-(trifluoromethyl)pyrimidin-2-yl]carbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: chloroform / 20 °C

2.1: hydrogen; ammonia / Rany-Ni / ethanol / 5 h / 20 °C

3.1: sodium methylate; methanol / 1.5 h / Reflux

4.1: trifluoroacetic acid / dichloromethane / 10 °C

4.2: 100 °C

5.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 18 h / 100 °C / Inert atmosphere

6.1: caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / palladium diacetate / 1,4-dioxane / 5 h / 125 °C / Inert atmosphere; sealed tube

7.1: dmap; triethylamine / tetrahydrofuran / 60 h / 20 °C / Inert atmosphere

With methanol; dmap; ammonia; hydrogen; sodium methylate; sodium carbonate; caesium carbonate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; ethanol; dichloromethane; chloroform; water;

Reference yield:

: 266353-18-8
N-tert-butoxycarbonyl-2-(2-cyanoethyl)aminoacetic acid ethyl ester

: 1312572-77-2
tert-butyl {3-nitro-5-[2-(3-oxo-1,4-diazepan-1-yl)-1,3-thiazol-5-yl]phenyl}[4-(trifluoromethyl)pyrimidin-2-yl]carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogen; ammonia / Rany-Ni / ethanol / 5 h / 20 °C

2.1: sodium methylate; methanol / 1.5 h / Reflux

3.1: trifluoroacetic acid / dichloromethane / 10 °C

3.2: 100 °C

4.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 18 h / 100 °C / Inert atmosphere

5.1: caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / palladium diacetate / 1,4-dioxane / 5 h / 125 °C / Inert atmosphere; sealed tube

6.1: dmap; triethylamine / tetrahydrofuran / 60 h / 20 °C / Inert atmosphere

With methanol; dmap; ammonia; hydrogen; sodium methylate; sodium carbonate; caesium carbonate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; ethanol; dichloromethane; water;