1-(2,2,2-trifluoroacetylamino)cyclopropanecarboxylic acid {(rac)-3-[5-chloro-3-fluoro-2-(5-methyl-[1,2,4]oxadiazol-3-yl)phenyl]-6,7-dihydro-5H-[1]pyrindin-7-yl}amide

Base Information

Chemical Name:1-(2,2,2-trifluoroacetylamino)cyclopropanecarboxylic acid {(rac)-3-[5-chloro-3-fluoro-2-(5-methyl-[1,2,4]oxadiazol-3-yl)phenyl]-6,7-dihydro-5H-[1]pyrindin-7-yl}amide
CAS No.:1392073-22-1
Molecular Formula:C₂₃H₁₈ClF₄N₅O₃
Molecular Weight:523.874
Hs Code.:

1-(2,2,2-trifluoroacetylamino)cyclopropanecarboxylic acid {(rac)-3-[5-chloro-3-fluoro-2-(5-methyl-[1,2,4]oxadiazol-3-yl)phenyl]-6,7-dihydro-5H-[1]pyrindin-7-yl}amide

Synonyms:1-(2,2,2-trifluoroacetylamino)cyclopropanecarboxylic acid {(rac)-3-[5-chloro-3-fluoro-2-(5-methyl-[1,2,4]oxadiazol-3-yl)phenyl]-6,7-dihydro-5H-[1]pyrindin-7-yl}amide

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Chemical Property of 1-(2,2,2-trifluoroacetylamino)cyclopropanecarboxylic acid {(rac)-3-[5-chloro-3-fluoro-2-(5-methyl-[1,2,4]oxadiazol-3-yl)phenyl]-6,7-dihydro-5H-[1]pyrindin-7-yl}amide

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Technology Process of 1-(2,2,2-trifluoroacetylamino)cyclopropanecarboxylic acid {(rac)-3-[5-chloro-3-fluoro-2-(5-methyl-[1,2,4]oxadiazol-3-yl)phenyl]-6,7-dihydro-5H-[1]pyrindin-7-yl}amide

There total 8 articles about 1-(2,2,2-trifluoroacetylamino)cyclopropanecarboxylic acid {(rac)-3-[5-chloro-3-fluoro-2-(5-methyl-[1,2,4]oxadiazol-3-yl)phenyl]-6,7-dihydro-5H-[1]pyrindin-7-yl}amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 858414-23-0
3-(2-bromo-4-chloro-6-fluorophenyl)-5-methyl-[1,2,4]oxadiazole

: 1392072-29-5
1-(2,2,2-trifluoroacetylamino)-cyclopropanecarboxylic acid ((rac)-3-bromo-6,7-dihydro-5H-[1]pyrindin-7-yl)-amide

: 73183-34-3
bis(pinacol)diborane

: 1392073-22-1
1-(2,2,2-trifluoroacetylamino)cyclopropanecarboxylic acid {(rac)-3-[5-chloro-3-fluoro-2-(5-methyl-[1,2,4]oxadiazol-3-yl)phenyl]-6,7-dihydro-5H-[1]pyrindin-7-yl}amide

Guidance literature:: 1-(2,2,2-trifluoroacetylamino)-cyclopropanecarboxylic acid ((rac)-3-bromo-6,7-dihydro-5H-[1]pyrindin-7-yl)-amide; bis(pinacol)diborane; With potassium acetate; potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In dimethyl sulfoxide; Inert atmosphere;

3-(2-bromo-4-chloro-6-fluorophenyl)-5-methyl-[1,2,4]oxadiazole; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In water; dimethyl sulfoxide; at 90 ℃; for 1.5h; Inert atmosphere;

3-(2-bromo-4-chloro-6-fluorophenyl)-5-methyl-[1,2,4]oxadiazole; In dichloromethane; water; dimethyl sulfoxide; at 80 ℃; for 3h;

Reference yield:

: 858414-23-0
3-(2-bromo-4-chloro-6-fluorophenyl)-5-methyl-[1,2,4]oxadiazole

: C₂₀H₂₅BF₃N₃O₄

: 1392073-22-1
1-(2,2,2-trifluoroacetylamino)cyclopropanecarboxylic acid {(rac)-3-[5-chloro-3-fluoro-2-(5-methyl-[1,2,4]oxadiazol-3-yl)phenyl]-6,7-dihydro-5H-[1]pyrindin-7-yl}amide

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; potassium carbonate; In water; dimethyl sulfoxide; at 80 ℃; for 3h; Inert atmosphere;

Reference yield:

: 1135531-73-5
2-bromo-4-chloro-6-fluorobenzaldehyde

: 1392073-22-1
1-(2,2,2-trifluoroacetylamino)cyclopropanecarboxylic acid {(rac)-3-[5-chloro-3-fluoro-2-(5-methyl-[1,2,4]oxadiazol-3-yl)phenyl]-6,7-dihydro-5H-[1]pyrindin-7-yl}amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydroxylamine / isopropyl alcohol; water / 2 h / 25 - 40 °C / Inert atmosphere

2.1: N,N-dimethylacetamide dimethyl acetal / isopropyl alcohol / 0.5 h / 25 °C / Inert atmosphere

3.1: potassium carbonate; potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / dimethyl sulfoxide / Inert atmosphere

3.2: 1.5 h / 90 °C / Inert atmosphere

3.3: 3 h / 80 °C

With N,N-dimethylacetamide dimethyl acetal; potassium acetate; hydroxylamine; potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In water; dimethyl sulfoxide; isopropyl alcohol;