2-<(1R)-2-(2,4-difluorophenyl)-2-oxo-1-methylethyl>-4-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-3(2H,4H)-1,2,4-triazolone

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Chemical Name:2-<(1R)-2-(2,4-difluorophenyl)-2-oxo-1-methylethyl>-4-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-3(2H,4H)-1,2,4-triazolone
CAS No.:174563-17-8
Molecular Formula:C₂₀H₁₅F₆N₃O₃
Molecular Weight:459.348
Hs Code.:

Synonyms:2-<(1R)-2-(2,4-difluorophenyl)-2-oxo-1-methylethyl>-4-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-3(2H,4H)-1,2,4-triazolone

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Chemical Property of 2-<(1R)-2-(2,4-difluorophenyl)-2-oxo-1-methylethyl>-4-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-3(2H,4H)-1,2,4-triazolone

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Technology Process of 2-<(1R)-2-(2,4-difluorophenyl)-2-oxo-1-methylethyl>-4-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-3(2H,4H)-1,2,4-triazolone

There total 6 articles about 2-<(1R)-2-(2,4-difluorophenyl)-2-oxo-1-methylethyl>-4-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-3(2H,4H)-1,2,4-triazolone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

1N-hydrochloric acid: 1N-hydrochloric acid

: 372-18-9
1,3-Difluorobenzene

: 174563-11-2
(2R)-2-[4-[4-(2,2,3,3-tetrafluoropropoxy)phenyl]-4,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]propanoyl chloride

: 174563-17-8
2-<(1R)-2-(2,4-difluorophenyl)-2-oxo-1-methylethyl>-4-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-3(2H,4H)-1,2,4-triazolone

Guidance literature:: With sodium chloride; aluminium chloride; In (2S)-N-methyl-1-phenylpropan-2-amine hydrate; dichloromethane; di-isopropyl ether; ethyl acetate;

Reference yield:

: 155431-64-4
4-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-3(2H,4H)-1,2,4-triazolone

: 174563-08-7
(2S)-2',4'-difluoro-2-trifluoromethanesulfonyloxypropiophenone

: 174563-17-8
2-<(1R)-2-(2,4-difluorophenyl)-2-oxo-1-methylethyl>-4-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-3(2H,4H)-1,2,4-triazolone

Guidance literature:: With sodium chloride; acetic acid; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; di-isopropyl ether; ethyl acetate;

Reference yield:

: 174563-09-8
benzyl (2R)-2-<4-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-4,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl>propanoate

: 174563-17-8
2-<(1R)-2-(2,4-difluorophenyl)-2-oxo-1-methylethyl>-4-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-3(2H,4H)-1,2,4-triazolone

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / 10 percent Pd/C / ethanol / 760 Torr / Ambient temperature

2: (COCl)2, DMF / CH₂Cl₂ / 2 h / Ambient temperature

3: AlCl₃ / CH₂Cl₂ / 8 h / Heating

With aluminium trichloride; oxalyl dichloride; hydrogen; N,N-dimethyl-formamide; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1248/cpb.47.360