4-methyl-N-((2R,3S,4S,4aS)-3,4a,8,8-tetramethyl-4-((4-(trifluoromethyl)benzamido)methyl)-decahydronaphthalen-2-yl)piperazine-1-carboxamide

Base Information

Chemical Name:4-methyl-N-((2R,3S,4S,4aS)-3,4a,8,8-tetramethyl-4-((4-(trifluoromethyl)benzamido)methyl)-decahydronaphthalen-2-yl)piperazine-1-carboxamide
CAS No.:1619983-91-3
Molecular Formula:C₂₉H₄₃F₃N₄O₂
Molecular Weight:536.681
Hs Code.:

Synonyms:4-methyl-N-((2R,3S,4S,4aS)-3,4a,8,8-tetramethyl-4-((4-(trifluoromethyl)benzamido)methyl)-decahydronaphthalen-2-yl)piperazine-1-carboxamide

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Chemical Property of 4-methyl-N-((2R,3S,4S,4aS)-3,4a,8,8-tetramethyl-4-((4-(trifluoromethyl)benzamido)methyl)-decahydronaphthalen-2-yl)piperazine-1-carboxamide

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Technology Process of 4-methyl-N-((2R,3S,4S,4aS)-3,4a,8,8-tetramethyl-4-((4-(trifluoromethyl)benzamido)methyl)-decahydronaphthalen-2-yl)piperazine-1-carboxamide

There total 13 articles about 4-methyl-N-((2R,3S,4S,4aS)-3,4a,8,8-tetramethyl-4-((4-(trifluoromethyl)benzamido)methyl)-decahydronaphthalen-2-yl)piperazine-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 455-24-3
4-trifluoromethylbenzoic acid

: 1619984-61-0
C₂₁H₄₀N₄O

: 1619983-91-3
4-methyl-N-((2R,3S,4S,4aS)-3,4a,8,8-tetramethyl-4-((4-(trifluoromethyl)benzamido)methyl)-decahydronaphthalen-2-yl)piperazine-1-carboxamide

Guidance literature:: With dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 22h; Inert atmosphere;

Reference yield:

: 105426-71-9
(1S,4aS,8aS)-1,4,4a,5,6,7,8,8a-octahydro-2,5,58a-tetramethylnaphtahelene-1-carboxaldehyde

: 1619983-91-3
4-methyl-N-((2R,3S,4S,4aS)-3,4a,8,8-tetramethyl-4-((4-(trifluoromethyl)benzamido)methyl)-decahydronaphthalen-2-yl)piperazine-1-carboxamide

Guidance literature:: Multi-step reaction with 13 steps

1.1: sodium tetrahydroborate; methanol / 72 h / 0 - 20 °C / Inert atmosphere

2.1: 1H-imidazole / N,N-dimethyl-formamide / 18 h / 0 - 20 °C / Inert atmosphere

3.1: borane-THF / tetrahydrofuran / 20 h / 0 - 20 °C / Inert atmosphere

3.2: 3 h / 0 °C / Reflux

4.1: 2-iodoxybenzoic acid / acetonitrile / 3.5 h / 75 °C / Inert atmosphere

5.1: sodium hydroxide / tetrahydrofuran; methanol; water / 1.5 h / Reflux

6.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 17 h / 20 °C / Inert atmosphere

7.1: palladium 10% on activated carbon; ammonium formate / methanol; ethyl acetate / 18 h / Reflux; Inert atmosphere

8.1: triethylamine / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere

9.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / Inert atmosphere; Reflux

10.1: pyridine / dichloromethane / 1 h / 0 °C / Inert atmosphere

11.1: sodium azide / N,N-dimethyl-formamide / 7 h / 50 °C / Inert atmosphere

12.1: water; triphenylphosphine / tetrahydrofuran / 96 h / 20 °C

13.1: dicyclohexyl-carbodiimide / dichloromethane / 22 h / 20 °C / Inert atmosphere

With pyridine; 1H-imidazole; methanol; sodium tetrahydroborate; sodium azide; borane-THF; 2-iodoxybenzoic acid; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; water; ammonium formate; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; dicyclohexyl-carbodiimide; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 468-68-8
(-)-drimenol

: 1619983-91-3
4-methyl-N-((2R,3S,4S,4aS)-3,4a,8,8-tetramethyl-4-((4-(trifluoromethyl)benzamido)methyl)-decahydronaphthalen-2-yl)piperazine-1-carboxamide

Guidance literature:: Multi-step reaction with 12 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 18 h / 0 - 20 °C / Inert atmosphere

2.1: borane-THF / tetrahydrofuran / 20 h / 0 - 20 °C / Inert atmosphere

2.2: 3 h / 0 °C / Reflux

3.1: 2-iodoxybenzoic acid / acetonitrile / 3.5 h / 75 °C / Inert atmosphere

4.1: sodium hydroxide / tetrahydrofuran; methanol; water / 1.5 h / Reflux

5.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 17 h / 20 °C / Inert atmosphere

6.1: palladium 10% on activated carbon; ammonium formate / methanol; ethyl acetate / 18 h / Reflux; Inert atmosphere

7.1: triethylamine / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere

8.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / Inert atmosphere; Reflux

9.1: pyridine / dichloromethane / 1 h / 0 °C / Inert atmosphere

10.1: sodium azide / N,N-dimethyl-formamide / 7 h / 50 °C / Inert atmosphere

11.1: water; triphenylphosphine / tetrahydrofuran / 96 h / 20 °C

12.1: dicyclohexyl-carbodiimide / dichloromethane / 22 h / 20 °C / Inert atmosphere

With pyridine; 1H-imidazole; sodium azide; borane-THF; 2-iodoxybenzoic acid; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; water; ammonium formate; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; dicyclohexyl-carbodiimide; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;