C-{1-[2,4-dimethyl-3-(2-methyl-quinolin-8-yloxymethyl)-phenyl]-pyrrolidin-2-yl}-methylamine

Base Information

Chemical Name:C-{1-[2,4-dimethyl-3-(2-methyl-quinolin-8-yloxymethyl)-phenyl]-pyrrolidin-2-yl}-methylamine
CAS No.:617721-56-9
Molecular Formula:C₂₄H₂₉N₃O
Molecular Weight:375.514
Hs Code.:

<i>C</i>-{1-[2,4-dimethyl-3-(2-methyl-quinolin-8-yloxymethyl)-phenyl]-pyrrolidin-2-yl}-methylamine

Synonyms:C-{1-[2,4-dimethyl-3-(2-methyl-quinolin-8-yloxymethyl)-phenyl]-pyrrolidin-2-yl}-methylamine

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Chemical Property of C-{1-[2,4-dimethyl-3-(2-methyl-quinolin-8-yloxymethyl)-phenyl]-pyrrolidin-2-yl}-methylamine

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Technology Process of C-{1-[2,4-dimethyl-3-(2-methyl-quinolin-8-yloxymethyl)-phenyl]-pyrrolidin-2-yl}-methylamine

There total 10 articles about C-{1-[2,4-dimethyl-3-(2-methyl-quinolin-8-yloxymethyl)-phenyl]-pyrrolidin-2-yl}-methylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.1%

: 597543-26-5
2-{1-[2,4-dimethyl-3-(2-methyl-quinolin-8-yloxymethyl)-phenyl]-pyrrolidin-2-(R)-ylmethyl}-isoindole-1,3-dione

: 617721-56-9
C-{1-[2,4-dimethyl-3-(2-methyl-quinolin-8-yloxymethyl)-phenyl]-pyrrolidin-2-yl}-methylamine

Guidance literature:: With hydrazine; In ethanol; at 20 ℃;

Reference yield:

: 826-81-3
2-methyl-8-quinolinol

: 617721-56-9
C-{1-[2,4-dimethyl-3-(2-methyl-quinolin-8-yloxymethyl)-phenyl]-pyrrolidin-2-yl}-methylamine

Guidance literature:: Multi-step reaction with 7 steps

1: TMAD; (n-Bu)3P

2: Pd₂(dba)3; (t-Bu)3P; NaOtBu / toluene

3: TFA / CH₂Cl₂

4: Et₃N

5: NaBH₄ / H₂O

6: TMAD; (n-Bu)3P

7: hydrazine / ethanol

With sodium tetrahydroborate; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; tributylphosphine; tri-tert-butyl phosphine; diamide; triethylamine; trifluoroacetic acid; sodium t-butanolate; hydrazine; In ethanol; dichloromethane; water; toluene; 1: Mitsunobu coupling / 2: Buchwald-Hartwig coupling / 6: Mitsunobu coupling;
DOI:10.1016/S0960-894X(03)00309-3

Reference yield:

: 632-46-2
2,6-dimethylbenzoic acid

: 617721-56-9
C-{1-[2,4-dimethyl-3-(2-methyl-quinolin-8-yloxymethyl)-phenyl]-pyrrolidin-2-yl}-methylamine

Guidance literature:: Multi-step reaction with 9 steps

1: Br₂; AcOH

2: BH₃-SMe₂

3: TMAD; (n-Bu)3P

4: Pd₂(dba)3; (t-Bu)3P; NaOtBu / toluene

5: TFA / CH₂Cl₂

6: Et₃N

7: NaBH₄ / H₂O

8: TMAD; (n-Bu)3P

9: hydrazine / ethanol

With sodium tetrahydroborate; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; tributylphosphine; tri-tert-butyl phosphine; dimethylsulfide borane complex; diamide; bromine; acetic acid; triethylamine; trifluoroacetic acid; sodium t-butanolate; hydrazine; In ethanol; dichloromethane; water; toluene; 3: Mitsunobu coupling / 4: Buchwald-Hartwig coupling / 8: Mitsunobu coupling;
DOI:10.1016/S0960-894X(03)00309-3