2-(benzhydrylidene-amino)-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid methyl ester

Base Information

• Chemical Name: 2-(benzhydrylidene-amino)-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid methyl ester
• CAS No.: 900492-90-2
• Molecular Formula: C₂₅H₂₃NO₂
• Molecular Weight: 369.463
• Mol file: 900492-90-2.mol

Synonyms:2-(benzhydrylidene-amino)-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid methyl ester

Chemical Property of 2-(benzhydrylidene-amino)-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(benzhydrylidene-amino)-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid methyl ester

There total 3 articles about 2-(benzhydrylidene-amino)-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-trifluoromethanesulfonyloxy-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid methyl ester (846540-87-2) + Benzophenone imine (1013-88-3) → 2-(benzhydrylidene-amino)-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid methyl ester (900492-90-2)

Guidance literature:

With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 100 ℃; for 4h;

DOI:10.1021/jm0601001

Reference yield:

methyl 2-hydroxy-1-naphthoate (947-65-9) → 2-(benzhydrylidene-amino)-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid methyl ester (900492-90-2)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂ / Pd/C / methanol; H₂O

2: pyridine / CH₂Cl₂

3: Pd(OAc)2; xantphos; Cs₂CO₃ / dioxane

With pyridine; palladium diacetate; hydrogen; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; palladium on activated charcoal; In 1,4-dioxane; methanol; dichloromethane; water;

DOI:10.1016/j.bmcl.2006.03.085

Reference yield:

2-hydroxy-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid methyl ester (59604-96-5) → 2-(benzhydrylidene-amino)-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid methyl ester (900492-90-2)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / CH₂Cl₂

2: Pd(OAc)2; xantphos; Cs₂CO₃ / dioxane

With pyridine; palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; dichloromethane;

DOI:10.1016/j.bmcl.2006.03.085

upstream raw materials:

2-trifluoromethanesulfonyloxy-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid methyl ester

Benzophenone imine

methyl 2-hydroxy-1-naphthoate

2-hydroxy-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid methyl ester

Downstream raw materials:

methyl 2-(N-(2-trimethylsilylethoxymethyl)-{[2-((Z)-3-hydroxyprop-1-enyl)-4-fluorophenyl]sulfonyl}amino)-5,6,7,8-tetrahydro-1-naphthalenecarboxylate