4-ethyl 1-(phenylmethyl) 5-(3,4-dichlorophenyl)-3,6-dihydro-1,4(2H)-pyridinedicarboxylate

Base Information

Chemical Name:4-ethyl 1-(phenylmethyl) 5-(3,4-dichlorophenyl)-3,6-dihydro-1,4(2H)-pyridinedicarboxylate
CAS No.:1010684-93-1
Molecular Formula:C₂₂H₂₁Cl₂NO₄
Molecular Weight:434.319
Hs Code.:

Synonyms:4-ethyl 1-(phenylmethyl) 5-(3,4-dichlorophenyl)-3,6-dihydro-1,4(2H)-pyridinedicarboxylate

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Chemical Property of 4-ethyl 1-(phenylmethyl) 5-(3,4-dichlorophenyl)-3,6-dihydro-1,4(2H)-pyridinedicarboxylate

Chemical Property:

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Technology Process of 4-ethyl 1-(phenylmethyl) 5-(3,4-dichlorophenyl)-3,6-dihydro-1,4(2H)-pyridinedicarboxylate

There total 4 articles about 4-ethyl 1-(phenylmethyl) 5-(3,4-dichlorophenyl)-3,6-dihydro-1,4(2H)-pyridinedicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1010684-92-0
ethyl 5-(3,4-dichlorophenyl)-1,2,3,6-tetrahydro-4-pyridinecarboxylate

: 501-53-1,94274-21-2
benzyl chloroformate

: 1010684-93-1
4-ethyl 1-(phenylmethyl) 5-(3,4-dichlorophenyl)-3,6-dihydro-1,4(2H)-pyridinedicarboxylate

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 2h;

Reference yield:

: 1010684-91-9
4-butanoyl-1-(phenylmethyl)-1,2,5,6-tetrahydro-3-pyridinyl-trifluoromethanesulfonate

: 1010684-93-1
4-ethyl 1-(phenylmethyl) 5-(3,4-dichlorophenyl)-3,6-dihydro-1,4(2H)-pyridinedicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 5 h / 80 °C

2: carbonochloridic acid 1-chloro-ethyl ester / 1,2-dichloro-ethane / 5 h / 50 °C

3: triethylamine / dichloromethane / 2 h / 0 - 20 °C

With carbonochloridic acid 1-chloro-ethyl ester; potassium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; dichloromethane; 1,2-dichloro-ethane;

Reference yield:

: 1010684-90-8
4-butanoyl-3-oxo-1-(phenylmethyl)piperidinium chloride

: 1010684-93-1
4-ethyl 1-(phenylmethyl) 5-(3,4-dichlorophenyl)-3,6-dihydro-1,4(2H)-pyridinedicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C

1.2: 4 h / 20 °C

2.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 5 h / 80 °C

3.1: carbonochloridic acid 1-chloro-ethyl ester / 1,2-dichloro-ethane / 5 h / 50 °C

4.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

With carbonochloridic acid 1-chloro-ethyl ester; sodium hydride; potassium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;