phenylmethyl 5-(3,4-dichlorophenyl)-4-(hydroxymethyl)-3,6-dihydro-1(2H)-pyridinecarboxylate

Base Information

Chemical Name:phenylmethyl 5-(3,4-dichlorophenyl)-4-(hydroxymethyl)-3,6-dihydro-1(2H)-pyridinecarboxylate
CAS No.:1010684-94-2
Molecular Formula:C₂₀H₁₉Cl₂NO₃
Molecular Weight:392.282
Hs Code.:

Synonyms:phenylmethyl 5-(3,4-dichlorophenyl)-4-(hydroxymethyl)-3,6-dihydro-1(2H)-pyridinecarboxylate

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Chemical Property of phenylmethyl 5-(3,4-dichlorophenyl)-4-(hydroxymethyl)-3,6-dihydro-1(2H)-pyridinecarboxylate

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Technology Process of phenylmethyl 5-(3,4-dichlorophenyl)-4-(hydroxymethyl)-3,6-dihydro-1(2H)-pyridinecarboxylate

There total 4 articles about phenylmethyl 5-(3,4-dichlorophenyl)-4-(hydroxymethyl)-3,6-dihydro-1(2H)-pyridinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1010684-93-1
4-ethyl 1-(phenylmethyl) 5-(3,4-dichlorophenyl)-3,6-dihydro-1,4(2H)-pyridinedicarboxylate

: 1010684-94-2
phenylmethyl 5-(3,4-dichlorophenyl)-4-(hydroxymethyl)-3,6-dihydro-1(2H)-pyridinecarboxylate

Guidance literature:: 4-ethyl 1-(phenylmethyl) 5-(3,4-dichlorophenyl)-3,6-dihydro-1,4(2H)-pyridinedicarboxylate; With lithium aluminium tetrahydride; In tetrahydrofuran; toluene; at -20 ℃; for 2h;

With water; ammonium chloride; In tetrahydrofuran; toluene;

Reference yield:

: 1010684-91-9
4-butanoyl-1-(phenylmethyl)-1,2,5,6-tetrahydro-3-pyridinyl-trifluoromethanesulfonate

: 1010684-94-2
phenylmethyl 5-(3,4-dichlorophenyl)-4-(hydroxymethyl)-3,6-dihydro-1(2H)-pyridinecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 5 h / 80 °C

2: carbonochloridic acid 1-chloro-ethyl ester / 1,2-dichloro-ethane / 5 h / 50 °C

3: triethylamine / dichloromethane / 2 h / 0 - 20 °C

4: lithium aluminium tetrahydride / tetrahydrofuran; toluene / 2 h / -20 °C

With lithium aluminium tetrahydride; carbonochloridic acid 1-chloro-ethyl ester; potassium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; 1,2-dichloro-ethane; toluene;

Reference yield:

: 1010684-90-8
4-butanoyl-3-oxo-1-(phenylmethyl)piperidinium chloride

: 1010684-94-2
phenylmethyl 5-(3,4-dichlorophenyl)-4-(hydroxymethyl)-3,6-dihydro-1(2H)-pyridinecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C

1.2: 4 h / 20 °C

2.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 5 h / 80 °C

3.1: carbonochloridic acid 1-chloro-ethyl ester / 1,2-dichloro-ethane / 5 h / 50 °C

4.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

5.1: lithium aluminium tetrahydride / tetrahydrofuran; toluene / 2 h / -20 °C

With lithium aluminium tetrahydride; carbonochloridic acid 1-chloro-ethyl ester; sodium hydride; potassium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;