2-(4-{4-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperazin-1-yl}phenoxy)ethyl methanesulfonate

Base Information

Chemical Name:2-(4-{4-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperazin-1-yl}phenoxy)ethyl methanesulfonate
CAS No.:1255340-96-5
Molecular Formula:C₁₉H₂₁F₃N₆O₄S
Molecular Weight:486.475
Hs Code.:

Synonyms:2-(4-{4-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperazin-1-yl}phenoxy)ethyl methanesulfonate

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Chemical Property of 2-(4-{4-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperazin-1-yl}phenoxy)ethyl methanesulfonate

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Technology Process of 2-(4-{4-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperazin-1-yl}phenoxy)ethyl methanesulfonate

There total 1 articles about 2-(4-{4-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperazin-1-yl}phenoxy)ethyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1255340-94-3
2-(4-{4-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperazin-1-yl}phenoxy)ethanol

: 124-63-0
methanesulfonyl chloride

: 1255340-96-5
2-(4-{4-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperazin-1-yl}phenoxy)ethyl methanesulfonate

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

Reference yield: 35.0%

: 1255340-96-5
2-(4-{4-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperazin-1-yl}phenoxy)ethyl methanesulfonate

: 76003-29-7
4-(t-butyloxycarbonyl)piperazin-2-one

: 1255340-99-8
tert-butyl 3-oxo-4-[2-(4-{4-[3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperazin-1-yl}phenoxy)ethyl]piperazine-1-carboxylate

Guidance literature:: 4-(t-butyloxycarbonyl)piperazin-2-one; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 0.25h; Inert atmosphere;

2-(4-{4-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperazin-1-yl}phenoxy)ethyl methanesulfonate; In tetrahydrofuran; mineral oil; at 65 ℃; for 18h; Inert atmosphere;