3-(3-{[3-(2-cyano-ethoxy)-propyl]-[3-(4-methoxy-phenoxy)-propyl]-amino}-propoxy)-propionitrile

Base Information

Chemical Name:3-(3-{[3-(2-cyano-ethoxy)-propyl]-[3-(4-methoxy-phenoxy)-propyl]-amino}-propoxy)-propionitrile
CAS No.:644968-41-2
Molecular Formula:C₂₂H₃₃N₃O₄
Molecular Weight:403.522
Hs Code.:

Synonyms:3-(3-{[3-(2-cyano-ethoxy)-propyl]-[3-(4-methoxy-phenoxy)-propyl]-amino}-propoxy)-propionitrile

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Chemical Property of 3-(3-{[3-(2-cyano-ethoxy)-propyl]-[3-(4-methoxy-phenoxy)-propyl]-amino}-propoxy)-propionitrile

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Technology Process of 3-(3-{[3-(2-cyano-ethoxy)-propyl]-[3-(4-methoxy-phenoxy)-propyl]-amino}-propoxy)-propionitrile

There total 4 articles about 3-(3-{[3-(2-cyano-ethoxy)-propyl]-[3-(4-methoxy-phenoxy)-propyl]-amino}-propoxy)-propionitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 107-13-1,25014-41-9
acrylonitrile

: 644968-39-8
3-{(3-hydroxy-propyl)-[3-(4-methoxy-phenoxy)-propyl]-amino}-propan-1-ol

: 644968-41-2
3-(3-{[3-(2-cyano-ethoxy)-propyl]-[3-(4-methoxy-phenoxy)-propyl]-amino}-propoxy)-propionitrile

Guidance literature:: With sodium hydroxide; In water; at 20 ℃; for 15h;
DOI:10.1021/jo035072y

Reference yield:

: 644968-17-2
3-[(3-benzyloxy-propyl)-(2-tert-butoxycarbonyl-ethyl)-amino]-propionic acid tert-butyl ester

: 644968-41-2
3-(3-{[3-(2-cyano-ethoxy)-propyl]-[3-(4-methoxy-phenoxy)-propyl]-amino}-propoxy)-propionitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 84.8 percent / H₂ / Pd/C / ethyl acetate / 120 h / 20 °C

2: 91 percent / diisopropyl azidodicarboxylate; PPh₃ / tetrahydrofuran / 0.25 h / 80 °C

3: 99 percent / LiAlH₄ / tetrahydrofuran / 1.5 h / 0 - 20 °C

4: 90 percent / NaOH / H₂O / 15 h / 20 °C

With sodium hydroxide; lithium aluminium tetrahydride; di-isopropyl azodicarboxylate; hydrogen; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; water; ethyl acetate; 2: Mitsunobu reaction / 4: Michael addition;
DOI:10.1021/jo035072y

Reference yield:

: 644968-23-0
tert-butyl 3-[(2-tert-butoxycarbonyl-ethyl)-(3-hydroxy-propyl)-amino]-propionate

: 644968-41-2
3-(3-{[3-(2-cyano-ethoxy)-propyl]-[3-(4-methoxy-phenoxy)-propyl]-amino}-propoxy)-propionitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / diisopropyl azidodicarboxylate; PPh₃ / tetrahydrofuran / 0.25 h / 80 °C

2: 99 percent / LiAlH₄ / tetrahydrofuran / 1.5 h / 0 - 20 °C

3: 90 percent / NaOH / H₂O / 15 h / 20 °C

With sodium hydroxide; lithium aluminium tetrahydride; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; water; 1: Mitsunobu reaction / 3: Michael addition;
DOI:10.1021/jo035072y