3-Hydroxy-2-(3-hydroxy-4-methoxy-phenyl)-5,7-dimethoxy-6-methoxymethoxy-chromen-4-one

Base Information

Chemical Name:3-Hydroxy-2-(3-hydroxy-4-methoxy-phenyl)-5,7-dimethoxy-6-methoxymethoxy-chromen-4-one
CAS No.:170234-72-7
Molecular Formula:C₂₀H₂₀O₉
Molecular Weight:404.373
Hs Code.:

Synonyms:3-Hydroxy-2-(3-hydroxy-4-methoxy-phenyl)-5,7-dimethoxy-6-methoxymethoxy-chromen-4-one

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Chemical Property of 3-Hydroxy-2-(3-hydroxy-4-methoxy-phenyl)-5,7-dimethoxy-6-methoxymethoxy-chromen-4-one

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Technology Process of 3-Hydroxy-2-(3-hydroxy-4-methoxy-phenyl)-5,7-dimethoxy-6-methoxymethoxy-chromen-4-one

There total 7 articles about 3-Hydroxy-2-(3-hydroxy-4-methoxy-phenyl)-5,7-dimethoxy-6-methoxymethoxy-chromen-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 170234-75-0
2-(3-Benzyloxy-4-methoxy-phenyl)-3-hydroxy-5,7-dimethoxy-6-methoxymethoxy-chromen-4-one

: 170234-72-7
3-Hydroxy-2-(3-hydroxy-4-methoxy-phenyl)-5,7-dimethoxy-6-methoxymethoxy-chromen-4-one

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; ethyl acetate;
DOI:10.1246/bcsj.68.2033

Reference yield:

: 170234-90-9
2-(3-Benzyloxy-4-methoxy-phenyl)-5,7-dimethoxy-6-methoxymethoxy-chromen-4-one

: 170234-72-7
3-Hydroxy-2-(3-hydroxy-4-methoxy-phenyl)-5,7-dimethoxy-6-methoxymethoxy-chromen-4-one

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) dimethyldioxirane, 2.) TsOH / 1.) CH₂Cl₂, Me₂CO, 0 deg C, 2.) CH₂Cl₂, 0 deg C, 0.5 h

2: 98 percent / H₂ / 10percent Pd/C / ethyl acetate; methanol

With hydrogen; 3,3-dimethyldioxirane; toluene-4-sulfonic acid; palladium on activated charcoal; In methanol; ethyl acetate;
DOI:10.1246/bcsj.68.2033

Reference yield:

: 6962-57-8
3,6-dihydroxy-2,4-dimethoxyacetophenone

: 170234-72-7
3-Hydroxy-2-(3-hydroxy-4-methoxy-phenyl)-5,7-dimethoxy-6-methoxymethoxy-chromen-4-one

Guidance literature:: Multi-step reaction with 7 steps

1: i-Pr₂NEt / CH₂Cl₂

2: pyridine / 50 - 60 °C

3: KOH, pyridine / 80 °C

4: 89 percent / conc. H₂SO₄, AcOH / 60 °C

5: 96 percent / i-Pr₂NEt / CH₂Cl₂ / Ambient temperature

6: 1.) dimethyldioxirane, 2.) TsOH / 1.) CH₂Cl₂, Me₂CO, 0 deg C, 2.) CH₂Cl₂, 0 deg C, 0.5 h

7: 98 percent / H₂ / 10percent Pd/C / ethyl acetate; methanol

With pyridine; potassium hydroxide; sulfuric acid; hydrogen; 3,3-dimethyldioxirane; toluene-4-sulfonic acid; acetic acid; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; dichloromethane; ethyl acetate;
DOI:10.1246/bcsj.68.2033