methyl 5-bromo-2-(4-fluorophenyl)-6-(N-methylphenylsulfonamido)benzofuran-3-carboxylate

Base Information

Chemical Name:methyl 5-bromo-2-(4-fluorophenyl)-6-(N-methylphenylsulfonamido)benzofuran-3-carboxylate
CAS No.:1333244-37-3
Molecular Formula:C₂₃H₁₇BrFNO₅S
Molecular Weight:518.36
Hs Code.:

Synonyms:methyl 5-bromo-2-(4-fluorophenyl)-6-(N-methylphenylsulfonamido)benzofuran-3-carboxylate

Suppliers and Price of methyl 5-bromo-2-(4-fluorophenyl)-6-(N-methylphenylsulfonamido)benzofuran-3-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of methyl 5-bromo-2-(4-fluorophenyl)-6-(N-methylphenylsulfonamido)benzofuran-3-carboxylate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of methyl 5-bromo-2-(4-fluorophenyl)-6-(N-methylphenylsulfonamido)benzofuran-3-carboxylate

There total 9 articles about methyl 5-bromo-2-(4-fluorophenyl)-6-(N-methylphenylsulfonamido)benzofuran-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1333244-36-2
methyl 5-bromo-2-(4-fluorophenyl)-6-(phenylsulfonamido)benzofuran-3-carboxylate

: 74-88-4
methyl iodide

: 1333244-37-3
methyl 5-bromo-2-(4-fluorophenyl)-6-(N-methylphenylsulfonamido)benzofuran-3-carboxylate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 40 ℃; for 15h; Inert atmosphere;

Reference yield:

: 1333225-30-1
methyl 2-(5-bromo-2-hydroxyphenyl)-3-(4-fluorophenyl)-3-oxopropanoate

: 1333244-37-3
methyl 5-bromo-2-(4-fluorophenyl)-6-(N-methylphenylsulfonamido)benzofuran-3-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogenchloride / water; acetone / 1 h / Reflux

2: nitric acid / chloroform / 4 h / 20 °C

3: ammonium chloride; iron / water; tetrahydrofuran; methanol / 3 h / Reflux

4: pyridine / dichloromethane / 15 h / 0 - 20 °C

5: potassium carbonate / N,N-dimethyl-formamide / 15 h / 40 °C / Inert atmosphere

With pyridine; hydrogenchloride; nitric acid; iron; potassium carbonate; ammonium chloride; In tetrahydrofuran; methanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; acetone;

Reference yield:

: 614-75-5
2-Hydroxyphenylacetic acid

: 1333244-37-3
methyl 5-bromo-2-(4-fluorophenyl)-6-(N-methylphenylsulfonamido)benzofuran-3-carboxylate

Guidance literature:: Multi-step reaction with 9 steps

1.1: tetra-N-butylammonium tribromide / 18 h / 20 °C

2.1: 1H-imidazole / dichloromethane / 15 h / 0 - 20 °C

3.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C

3.2: 1 h / -78 - 0 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 °C

5.1: hydrogenchloride / water; acetone / 1 h / Reflux

6.1: nitric acid / chloroform / 4 h / 20 °C

7.1: ammonium chloride; iron / water; tetrahydrofuran; methanol / 3 h / Reflux

8.1: pyridine / dichloromethane / 15 h / 0 - 20 °C

9.1: potassium carbonate / N,N-dimethyl-formamide / 15 h / 40 °C / Inert atmosphere

With pyridine; 1H-imidazole; hydrogenchloride; tetrabutyl ammonium fluoride; nitric acid; tetra-N-butylammonium tribromide; iron; potassium carbonate; ammonium chloride; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; acetone;