methyl 12-(3,4,5-trimethoxybenzyl)-1-oxo-2,3,4,12-tetrahydro-1H-benzo[2,3]indolizino[8,7-b]indole-6-carboxylate

Base Information

Chemical Name:methyl 12-(3,4,5-trimethoxybenzyl)-1-oxo-2,3,4,12-tetrahydro-1H-benzo[2,3]indolizino[8,7-b]indole-6-carboxylate
CAS No.:1379826-81-9
Molecular Formula:C₃₀H₂₈N₂O₆
Molecular Weight:512.562
Hs Code.:

Synonyms:methyl 12-(3,4,5-trimethoxybenzyl)-1-oxo-2,3,4,12-tetrahydro-1H-benzo[2,3]indolizino[8,7-b]indole-6-carboxylate

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Chemical Property of methyl 12-(3,4,5-trimethoxybenzyl)-1-oxo-2,3,4,12-tetrahydro-1H-benzo[2,3]indolizino[8,7-b]indole-6-carboxylate

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Technology Process of methyl 12-(3,4,5-trimethoxybenzyl)-1-oxo-2,3,4,12-tetrahydro-1H-benzo[2,3]indolizino[8,7-b]indole-6-carboxylate

There total 5 articles about methyl 12-(3,4,5-trimethoxybenzyl)-1-oxo-2,3,4,12-tetrahydro-1H-benzo[2,3]indolizino[8,7-b]indole-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1379826-80-8
methyl 1-(hydroxy(6-oxocyclohex-1-enyl)methyl)-9-(3,4,5-trimethoxybenzyl)-9H-pyrido[3,4-b]indole-3-carboxylate

: 1379826-81-9
methyl 12-(3,4,5-trimethoxybenzyl)-1-oxo-2,3,4,12-tetrahydro-1H-benzo[2,3]indolizino[8,7-b]indole-6-carboxylate

Guidance literature:: With phosphorus pentoxide; In dichloromethane; for 5h;
DOI:10.1002/ejoc.201200068

Reference yield:

: 21852-50-6
3,4,5-trimethoxybenzyl bromide

: 1379826-81-9
methyl 12-(3,4,5-trimethoxybenzyl)-1-oxo-2,3,4,12-tetrahydro-1H-benzo[2,3]indolizino[8,7-b]indole-6-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 0.25 h

1.2: 1 h

2.1: acetic acid / water / 0.75 h / 90 °C

3.1: 1,4-diaza-bicyclo[2.2.2]octane / 2 h

4.1: phosphorus pentoxide / dichloromethane / 5 h

With 1,4-diaza-bicyclo[2.2.2]octane; phosphorus pentoxide; caesium carbonate; acetic acid; In dichloromethane; water; N,N-dimethyl-formamide; 1.1: Friedel Crafts alkylation / 1.2: Friedel Crafts alkylation / 4.1: Friedel Crafts alkylation;
DOI:10.1002/ejoc.201200068

Reference yield:

: 1379826-11-5
methyl 1-(dimethoxymethyl)-9-(3,4,5-trimethoxybenzyl)-9H-carboline-3-carboxylate

: 1379826-81-9
methyl 12-(3,4,5-trimethoxybenzyl)-1-oxo-2,3,4,12-tetrahydro-1H-benzo[2,3]indolizino[8,7-b]indole-6-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid / water / 0.75 h / 90 °C

2: 1,4-diaza-bicyclo[2.2.2]octane / 2 h

3: phosphorus pentoxide / dichloromethane / 5 h

With 1,4-diaza-bicyclo[2.2.2]octane; phosphorus pentoxide; acetic acid; In dichloromethane; water; 3: Friedel Crafts alkylation;
DOI:10.1002/ejoc.201200068