(R)-4-allyl-3,4,5,6-tetrahydro-1H-benzo[f][1,4]oxazocine

Base Information

Chemical Name:(R)-4-allyl-3,4,5,6-tetrahydro-1H-benzo[f][1,4]oxazocine
CAS No.:1333115-22-2
Molecular Formula:C₁₃H₁₇NO
Molecular Weight:203.284
Hs Code.:

Synonyms:(R)-4-allyl-3,4,5,6-tetrahydro-1H-benzo[f][1,4]oxazocine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-4-allyl-3,4,5,6-tetrahydro-1H-benzo[f][1,4]oxazocine

Chemical Property:

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Technology Process of (R)-4-allyl-3,4,5,6-tetrahydro-1H-benzo[f][1,4]oxazocine

There total 1 articles about (R)-4-allyl-3,4,5,6-tetrahydro-1H-benzo[f][1,4]oxazocine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 54594-06-8
D-allylglycine

: 1333115-22-2
(R)-4-allyl-3,4,5,6-tetrahydro-1H-benzo[f][1,4]oxazocine

Guidance literature:: Multi-step reaction with 8 steps

1: hydrogenchloride / 70 °C

2: triethylamine / dichloromethane / 1 h / 20 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere; Cooling with ice

4: sodium hydride / tetrahydrofuran; mineral oil / 2 h / 20 °C / Inert atmosphere; Cooling with ice

5: sodium tetrahydroborate; calcium chloride / tetrahydrofuran; ethanol / 17 h / 20 °C / Inert atmosphere; Cooling with ice

6: phosphorus tribromide / tetrachloromethane / 2 h / 0 °C

7: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

8: potassium carbonate / ethanol / 2 h / Reflux

With hydrogenchloride; sodium tetrahydroborate; lithium aluminium tetrahydride; phosphorus tribromide; sodium hydride; potassium carbonate; triethylamine; trifluoroacetic acid; calcium chloride; In tetrahydrofuran; tetrachloromethane; ethanol; dichloromethane; mineral oil;

Reference yield:

: 1333115-22-2
(R)-4-allyl-3,4,5,6-tetrahydro-1H-benzo[f][1,4]oxazocine

: 1333115-34-6
(R)-N-(2-oxo-2-phenylethyl)-2-(5-(quinolin-8-ylsulfonyl)-3,4,5,6-tetrahydro-1H-benzo[f][1,4]oxazocin-4-yl)acetohvdrazide

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dmap / dichloromethane / 20 °C

2.1: sodium periodate; water / ruthenium trichloride / tetrachloromethane; acetonitrile / 16 h / 20 °C

3.1: thionyl chloride / 1 h / 20 °C

3.2: 1 h / 20 °C

With sodium periodate; thionyl chloride; water; triethylamine; dmap; ruthenium trichloride; In tetrachloromethane; dichloromethane; acetonitrile;

Reference yield:

: 1333115-22-2
(R)-4-allyl-3,4,5,6-tetrahydro-1H-benzo[f][1,4]oxazocine

: 1333115-35-7
(R)-4-((4-phenyl-1H-imidazol-2-yl)methyl)-5-(quinolin-8-ylsulfonyl)-3,4,5,6-tetrahydro-1H-benzo[f][1,4]oxazocine

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dmap / dichloromethane / 20 °C

2.1: sodium periodate; water / ruthenium trichloride / tetrachloromethane; acetonitrile / 16 h / 20 °C

3.1: thionyl chloride / 1 h / 20 °C

3.2: 1 h / 20 °C

4.1: ammonium acetate / N,N-dimethyl-formamide / 1 h / 150 °C / Sealed; microwave irradiation

With sodium periodate; thionyl chloride; ammonium acetate; water; triethylamine; dmap; ruthenium trichloride; In tetrachloromethane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;