(2S,3R)-1-(2-(3-hydroxypropyl)-1,3-dioxolan-2-yl)-3-(4-methoxyphenyl)-4-nitrobutan-2-ol

Base Information

Chemical Name:(2S,3R)-1-(2-(3-hydroxypropyl)-1,3-dioxolan-2-yl)-3-(4-methoxyphenyl)-4-nitrobutan-2-ol
CAS No.:1394131-93-1
Molecular Formula:C₁₇H₂₅NO₇
Molecular Weight:355.388
Hs Code.:

Synonyms:(2S,3R)-1-(2-(3-hydroxypropyl)-1,3-dioxolan-2-yl)-3-(4-methoxyphenyl)-4-nitrobutan-2-ol

Suppliers and Price of (2S,3R)-1-(2-(3-hydroxypropyl)-1,3-dioxolan-2-yl)-3-(4-methoxyphenyl)-4-nitrobutan-2-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,3R)-1-(2-(3-hydroxypropyl)-1,3-dioxolan-2-yl)-3-(4-methoxyphenyl)-4-nitrobutan-2-ol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,3R)-1-(2-(3-hydroxypropyl)-1,3-dioxolan-2-yl)-3-(4-methoxyphenyl)-4-nitrobutan-2-ol

There total 4 articles about (2S,3R)-1-(2-(3-hydroxypropyl)-1,3-dioxolan-2-yl)-3-(4-methoxyphenyl)-4-nitrobutan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1301743-47-4
(S)-7-((R)-1-(4-methoxyphenyl)-2-nitroethyl)-1,4,8-trioxaspiro[4.6]undecan-9-one

: 1394131-93-1
(2S,3R)-1-(2-(3-hydroxypropyl)-1,3-dioxolan-2-yl)-3-(4-methoxyphenyl)-4-nitrobutan-2-ol

Guidance literature:: With sodium tetrahydroborate; In ethanol; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1039/c2ob25689d

Reference yield:

: 4746-97-8
cyclohexanedione monoethylene ketal

: 1394131-93-1
(2S,3R)-1-(2-(3-hydroxypropyl)-1,3-dioxolan-2-yl)-3-(4-methoxyphenyl)-4-nitrobutan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1: N¹,N¹-dimethyl-N²-(((S)-pyrrolidin-2-yl)methyl)ethane-1,2-diamine; toluene-4-sulfonic acid / N,N-dimethyl-formamide / 48 h / 20 °C / Inert atmosphere

2: disodium phosphate heptahydrate; 3-chloro-benzenecarboperoxoic acid / dichloromethane / 16 h / 20 °C / Inert atmosphere

3: sodium tetrahydroborate / ethanol / 3 h / 20 °C / Inert atmosphere

With N¹,N¹-dimethyl-N²-(((S)-pyrrolidin-2-yl)methyl)ethane-1,2-diamine; sodium tetrahydroborate; disodium phosphate heptahydrate; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; In ethanol; dichloromethane; N,N-dimethyl-formamide; 1: Michael condensation / 2: Baeyer-Villiger oxidation;
DOI:10.1039/c2ob25689d

Reference yield:

: 1301743-46-3
(7S)-7-[(1R)-1-(4-methoxyphenyl)-2-nitroethyl]-1,4-dioxaspiro[4.5]decan-8-one

: 1394131-93-1
(2S,3R)-1-(2-(3-hydroxypropyl)-1,3-dioxolan-2-yl)-3-(4-methoxyphenyl)-4-nitrobutan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: disodium phosphate heptahydrate; 3-chloro-benzenecarboperoxoic acid / dichloromethane / 16 h / 20 °C / Inert atmosphere

2: sodium tetrahydroborate / ethanol / 3 h / 20 °C / Inert atmosphere

With sodium tetrahydroborate; disodium phosphate heptahydrate; 3-chloro-benzenecarboperoxoic acid; In ethanol; dichloromethane; 1: Baeyer-Villiger oxidation;
DOI:10.1039/c2ob25689d