(R)-2-{N-[(S)-1-(3-Benzyloxy-4-methoxy-phenyl)-but-3-enyl]aminooxy}-1-naphthalen-2-yl-ethanol

Base Information

• Chemical Name: (R)-2-{N-[(S)-1-(3-Benzyloxy-4-methoxy-phenyl)-but-3-enyl]aminooxy}-1-naphthalen-2-yl-ethanol
• CAS No.: 851755-88-9
• Molecular Formula: C₃₀H₃₁NO₄
• Molecular Weight: 469.58
• Mol file: 851755-88-9.mol

Synonyms:(R)-2-{N-[(S)-1-(3-Benzyloxy-4-methoxy-phenyl)-but-3-enyl]aminooxy}-1-naphthalen-2-yl-ethanol

Chemical Property of (R)-2-{N-[(S)-1-(3-Benzyloxy-4-methoxy-phenyl)-but-3-enyl]aminooxy}-1-naphthalen-2-yl-ethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-{N-[(S)-1-(3-Benzyloxy-4-methoxy-phenyl)-but-3-enyl]aminooxy}-1-naphthalen-2-yl-ethanol

There total 3 articles about (R)-2-{N-[(S)-1-(3-Benzyloxy-4-methoxy-phenyl)-but-3-enyl]aminooxy}-1-naphthalen-2-yl-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-benzyloxy-4-methoxy-benzaldehyde O-(2-hydroxy-2-naphthalen-2-yl-ethyl)-oxime (851755-87-8) + allyllithium (3052-45-7) → (R)-2-{N-[(S)-1-(3-Benzyloxy-4-methoxy-phenyl)-but-3-enyl]aminooxy}-1-naphthalen-2-yl-ethanol (851755-88-9) + (R)-2-{N-[(R)-1-(3-Benzyloxy-4-methoxy-phenyl)-but-3-enyl]aminooxy}-1-naphthalen-2-yl-ethanol

Guidance literature:

In diethyl ether; toluene; at 45 ℃; for 0.333333h;

DOI:10.1016/j.tetlet.2005.02.110

Reference yield:

3-benzyloxy-4-methoxybenzaldehyde (6346-05-0) → (R)-2-{N-[(S)-1-(3-Benzyloxy-4-methoxy-phenyl)-but-3-enyl]aminooxy}-1-naphthalen-2-yl-ethanol (851755-88-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / toluene / Heating

2: diethyl ether; toluene / 0.33 h / 45 °C

In diethyl ether; toluene;

DOI:10.1016/j.tetlet.2005.02.110

Reference yield:

(R)-1-(2-naphtyl)aminooxy ethanol → (R)-2-{N-[(S)-1-(3-Benzyloxy-4-methoxy-phenyl)-but-3-enyl]aminooxy}-1-naphthalen-2-yl-ethanol (851755-88-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / toluene / Heating

2: diethyl ether; toluene / 0.33 h / 45 °C

In diethyl ether; toluene;

DOI:10.1016/j.tetlet.2005.02.110

upstream raw materials:

3-benzyloxy-4-methoxy-benzaldehyde O-(2-hydroxy-2-naphthalen-2-yl-ethyl)-oxime

allyllithium

3-benzyloxy-4-methoxybenzaldehyde

Downstream raw materials:

(S)-1-(3-Benzyloxy-4-methoxy-phenyl)-but-3-enylamine

(S)-1-(3-Benzyloxy-4-methoxy-phenyl)-2-(2-methyl-[1,3]dioxolan-2-yl)-ethylamine

C₁₈H₂₅NO₄

5-[(7S,9S)-9-(4-Hydroxy-butyl)-1,4-dioxa-8-aza-spiro[4.5]dec-7-yl]-2-methoxy-phenol