Technology Process of N-(4'-(benzyloxy)-3-fluoro-1,2,3,6-tetrahydro-[1,1':2',1-terphenyl]-2-yl)acetamide
There total 8 articles about N-(4'-(benzyloxy)-3-fluoro-1,2,3,6-tetrahydro-[1,1':2',1-terphenyl]-2-yl)acetamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C
2: ammonium acetate / 0.33 h / 50 °C
3: toluene / 48 h / -78 - 120 °C / Sealed tube
4: hydrogenchloride; zinc / isopropyl alcohol / 1.5 h / 50 °C
5: triethylamine / dichloromethane / 3 h / 20 °C
6: hydrogenchloride / methanol / 50 °C
7: triethylamine / dichloromethane / 0 °C
8: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / N,N-dimethyl-formamide / Inert atmosphere; Sealed tube; Reflux
With
hydrogenchloride; tetrakis(triphenylphosphine) palladium(0); ammonium acetate; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; zinc;
In
methanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; toluene;
2: Henry reaction / 8: Suzuki coupling;
DOI:10.1021/jm300544c
- Guidance literature:
-
Multi-step reaction with 5 steps
1: hydrogenchloride; zinc / isopropyl alcohol / 1.5 h / 50 °C
2: triethylamine / dichloromethane / 3 h / 20 °C
3: hydrogenchloride / methanol / 50 °C
4: triethylamine / dichloromethane / 0 °C
5: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / N,N-dimethyl-formamide / Inert atmosphere; Sealed tube; Reflux
With
hydrogenchloride; tetrakis(triphenylphosphine) palladium(0); potassium carbonate; triethylamine; zinc;
In
methanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;
5: Suzuki coupling;
DOI:10.1021/jm300544c
- Guidance literature:
-
Multi-step reaction with 3 steps
1: hydrogenchloride / methanol / 50 °C
2: triethylamine / dichloromethane / 0 °C
3: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / N,N-dimethyl-formamide / Inert atmosphere; Sealed tube; Reflux
With
hydrogenchloride; tetrakis(triphenylphosphine) palladium(0); potassium carbonate; triethylamine;
In
methanol; dichloromethane; N,N-dimethyl-formamide;
3: Suzuki coupling;
DOI:10.1021/jm300544c
