N-(4'-(benzyloxy)-2'-(methoxymethoxy)-1,2,3,6-tetrahydro-[1,1'-biphenyl]-2-yl)acetamide

Base Information

Chemical Name:N-(4'-(benzyloxy)-2'-(methoxymethoxy)-1,2,3,6-tetrahydro-[1,1'-biphenyl]-2-yl)acetamide
CAS No.:1382722-64-6
Molecular Formula:C₂₃H₂₇NO₄
Molecular Weight:381.472
Hs Code.:

Synonyms:N-(4'-(benzyloxy)-2'-(methoxymethoxy)-1,2,3,6-tetrahydro-[1,1'-biphenyl]-2-yl)acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4'-(benzyloxy)-2'-(methoxymethoxy)-1,2,3,6-tetrahydro-[1,1'-biphenyl]-2-yl)acetamide

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Technology Process of N-(4'-(benzyloxy)-2'-(methoxymethoxy)-1,2,3,6-tetrahydro-[1,1'-biphenyl]-2-yl)acetamide

There total 8 articles about N-(4'-(benzyloxy)-2'-(methoxymethoxy)-1,2,3,6-tetrahydro-[1,1'-biphenyl]-2-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: C₂₁H₂₅NO₃

: 108-24-7
acetic anhydride

: 1382722-64-6
N-(4'-(benzyloxy)-2'-(methoxymethoxy)-1,2,3,6-tetrahydro-[1,1'-biphenyl]-2-yl)acetamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 3h; under 760.051 Torr;

Reference yield:

: 52085-14-0
4-benzoxy-salicylaldehyde

: 1382722-64-6
N-(4'-(benzyloxy)-2'-(methoxymethoxy)-1,2,3,6-tetrahydro-[1,1'-biphenyl]-2-yl)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

2: ammonium acetate / 0.33 h / 50 °C

3: toluene / 48 h / -78 - 120 °C / Sealed tube

4: hydrogenchloride; zinc / isopropyl alcohol / 1.5 h / 50 °C

5: triethylamine / dichloromethane / 3 h / 20 °C

With hydrogenchloride; ammonium acetate; triethylamine; N-ethyl-N,N-diisopropylamine; zinc; In dichloromethane; isopropyl alcohol; toluene; 2: Henry reaction;
DOI:10.1021/jm300544c

Reference yield:

: 1382722-63-5
4'-(benzyloxy)-2'-(methoxymethoxy)-2-nitro-1,2,3,6-tetrahydro-1,1'-biphenyl

: 1382722-64-6
N-(4'-(benzyloxy)-2'-(methoxymethoxy)-1,2,3,6-tetrahydro-[1,1'-biphenyl]-2-yl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride; zinc / isopropyl alcohol / 1.5 h / 50 °C

2: triethylamine / dichloromethane / 3 h / 20 °C

With hydrogenchloride; triethylamine; zinc; In dichloromethane; isopropyl alcohol;
DOI:10.1021/jm300544c