1-(4-hydroxymethylene-2-methyl-3-oxocyclohexylmethyl)-5-methoxy-1,2-dihydrocyclobutabenzene

Base Information

• Chemical Name: 1-(4-hydroxymethylene-2-methyl-3-oxocyclohexylmethyl)-5-methoxy-1,2-dihydrocyclobutabenzene
• CAS No.: 83637-56-3
• Molecular Formula: C₁₈H₂₂O₃
• Molecular Weight: 286.371
• Mol file: 83637-56-3.mol

Synonyms:1-(4-hydroxymethylene-2-methyl-3-oxocyclohexylmethyl)-5-methoxy-1,2-dihydrocyclobutabenzene

Chemical Property of 1-(4-hydroxymethylene-2-methyl-3-oxocyclohexylmethyl)-5-methoxy-1,2-dihydrocyclobutabenzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-hydroxymethylene-2-methyl-3-oxocyclohexylmethyl)-5-methoxy-1,2-dihydrocyclobutabenzene

There total 7 articles about 1-(4-hydroxymethylene-2-methyl-3-oxocyclohexylmethyl)-5-methoxy-1,2-dihydrocyclobutabenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

5-methoxy-1-(2-methyl-3-oxocyclohexylmethyl)-1,2-dihydrocyclobutabenzene (83637-55-2) + formic acid ethyl ester (109-94-4) → 1-(4-hydroxymethylene-2-methyl-3-oxocyclohexylmethyl)-5-methoxy-1,2-dihydrocyclobutabenzene (83637-56-3)

Guidance literature:

With sodium hydride; In benzene; for 3h; Ambient temperature;

Reference yield:

5-methoxybenzocyclobuten-1-yl toluene-p-sulphonate (30267-36-8) → 1-(4-hydroxymethylene-2-methyl-3-oxocyclohexylmethyl)-5-methoxy-1,2-dihydrocyclobutabenzene (83637-56-3)

Guidance literature:

Multi-step reaction with 7 steps

1: dimethylformamide

2: m-chloroperbenzoic acid / CH₂Cl₂

3: 38 percent / lithium di-isopropylamide / tetrahydrofuran

4: pyridinium chlorochromate / CH₂Cl₂

5: zinc / acetic acid

6: 70 percent / H₂ / Pd/C / methanol

7: NaH / benzene

With hydrogen; sodium hydride; 3-chloro-benzenecarboperoxoic acid; pyridinium chlorochromate; zinc; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; acetic acid; N,N-dimethyl-formamide; benzene;

DOI:10.1039/c39820000699

Reference yield:

5-methoxybenzocyclobut-1-enyl phenyl sulphide (83637-50-7) → 1-(4-hydroxymethylene-2-methyl-3-oxocyclohexylmethyl)-5-methoxy-1,2-dihydrocyclobutabenzene (83637-56-3)

Guidance literature:

Multi-step reaction with 6 steps

1: m-chloroperbenzoic acid / CH₂Cl₂

2: 38 percent / lithium di-isopropylamide / tetrahydrofuran

3: pyridinium chlorochromate / CH₂Cl₂

4: zinc / acetic acid

5: 70 percent / H₂ / Pd/C / methanol

6: NaH / benzene

With hydrogen; sodium hydride; 3-chloro-benzenecarboperoxoic acid; pyridinium chlorochromate; zinc; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; acetic acid; benzene;

DOI:10.1039/c39820000699

upstream raw materials:

5-methoxy-1-(2-methyl-3-oxocyclohexylmethyl)-1,2-dihydrocyclobutabenzene

formic acid ethyl ester

5-methoxybenzocyclobuten-1-yl toluene-p-sulphonate

5-methoxybenzocyclobut-1-enyl phenyl sulphide

Downstream raw materials:

Methanesulfonic acid 4-(4-methoxy-bicyclo[4.2.0]octa-1⁽⁶⁾,2,4-trien-7-ylmethyl)-3-methyl-2-oxo-cyclohex-(E)-ylidenemethyl ester

5-methoxy-1-(2-methyl-3-oxo-4-phenylthiomethylenecyclohexylmethyl)-1,2-dihydrocyclobutabenzene

3-methoxy-7-methyl-9-phenylthio-4bβ,5,6,8a,9,10-hexahydro-6α,8aα-ethanophenanthren-8(7H)-one

3-methoxy-7-methyl-9-phenylthio-4bα,5,6,8a,9,10-hexahydro-6α,8aα-ethanophenanthren-8(7H)-one