4-Methoxy-N-naphthalen-1-yl-benzamide

Base Information

• Chemical Name: 4-Methoxy-N-naphthalen-1-yl-benzamide
• CAS No.: 63295-63-6
• Molecular Formula: C18H15NO2
• Molecular Weight: 277.3172
• European Community (EC) Number: 668-216-3
• NSC Number: 191530
• DSSTox Substance ID: DTXSID50307470
• Nikkaji Number: J1.812.569B
• Wikidata: Q82054874
• ChEMBL ID: CHEMBL1520332
• Mol file: 63295-63-6.mol

Synonyms:4-methoxy-N-(naphthalen-1-yl)benzamide;63295-63-6;4-Methoxy-N-naphthalen-1-yl-benzamide;Benzamide, N-(1-naphthyl)-4-methoxy-;NSC191530;Oprea1_295983;Oprea1_478774;MLS001209134;CHEMBL1520332;4-methoxy-N-1-naphthylbenzamide;DTXSID50307470;OHTOZIGJSMXGDB-UHFFFAOYSA-N;HMS2816K12;AKOS000572598;NSC-191530;SMR000517310;4-METHOXY-N-(1-NAPHTHYL)BENZAMIDE

Chemical Property of 4-Methoxy-N-naphthalen-1-yl-benzamide

Chemical Property:

• Vapor Pressure: 1.81E-06mmHg at 25°C
• Boiling Point: 395.6°Cat760mmHg
• Flash Point: 193.1°C
• Density: 1.224g/cm³
• XLogP3: 3.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 277.110278721
• Heavy Atom Count: 21
• Complexity: 349

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C(=O)NC2=CC=CC3=CC=CC=C32

Technology Process of 4-Methoxy-N-naphthalen-1-yl-benzamide

There total 5 articles about 4-Methoxy-N-naphthalen-1-yl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

1-(4-methoxybenzoyl)naphtho[1,8-de][1,2,3]triazine (866226-20-2) → 2-(4-methoxyphenyl)naphto[1,8-de][1,3]oxazine + 4-methoxy-N-(naphthalen-1-yl)benzamide (63295-63-6)

Guidance literature:

With cyclohexene; at 170 ℃; under 0.045004 Torr; Further Variations:; Temperatures; Reagents; Pressures; Kinetics;

DOI:10.1016/j.tet.2005.08.047

Reference yield: 39.0%

1-Iodonaphthalene (90-14-2) + 4-methoxy-benzylamine (2393-23-9) → 4-methoxy-N-(naphthalen-1-yl)benzamide (63295-63-6)

Guidance literature:

With 1,10-Phenanthroline; oxygen; copper(II) bis(trifluoromethanesulfonate); potassium carbonate; In dimethyl sulfoxide; at 140 ℃; for 72h; Schlenk technique;

DOI:10.1002/adsc.201200424 DOI:10.1002/adsc.201200424

Reference yield:

4-methoxybenzoyl bromide (937-29-1) + 1-amino-naphthalene (134-32-7) → 4-methoxy-N-(naphthalen-1-yl)benzamide (63295-63-6)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1016/j.tetlet.2006.06.013

upstream raw materials:

1-amino-naphthalene

1-(4-methoxybenzoyl)naphtho[1,8-de][1,2,3]triazine

4-methoxybenzoyl bromide

4-methoxybenzoic acid

Downstream raw materials:

6-methoxy-2,3-diphenylisoquinolin-1(2H)-one

11-methoxy-5,6,13-triphenyl-8H-isoquinolino[3,2-a]isoquinolin-8-one