(+)-(3S,4R,5S)-1-tert-butoxycarbonyl-3-tert-butyldimethylsilyloxymethyl-4-phenyl-5-trimethylsilylpyrazolidine

Base Information

Chemical Name:(+)-(3S,4R,5S)-1-tert-butoxycarbonyl-3-tert-butyldimethylsilyloxymethyl-4-phenyl-5-trimethylsilylpyrazolidine
CAS No.:224572-01-4
Molecular Formula:C₂₄H₄₄N₂O₃Si₂
Molecular Weight:464.796
Hs Code.:

Synonyms:(+)-(3S,4R,5S)-1-tert-butoxycarbonyl-3-tert-butyldimethylsilyloxymethyl-4-phenyl-5-trimethylsilylpyrazolidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+)-(3S,4R,5S)-1-tert-butoxycarbonyl-3-tert-butyldimethylsilyloxymethyl-4-phenyl-5-trimethylsilylpyrazolidine

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Technology Process of (+)-(3S,4R,5S)-1-tert-butoxycarbonyl-3-tert-butyldimethylsilyloxymethyl-4-phenyl-5-trimethylsilylpyrazolidine

There total 7 articles about (+)-(3S,4R,5S)-1-tert-butoxycarbonyl-3-tert-butyldimethylsilyloxymethyl-4-phenyl-5-trimethylsilylpyrazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 224571-89-5
(-)-(4S,5S)-1-tert-butoxycarbonyl-3-tert-butyldimethylsilyloxymethyl-4,5-dihydro-4-phenyl-5-trimethylsilyl-1H-pyrazole

: 224572-01-4
(+)-(3S,4R,5S)-1-tert-butoxycarbonyl-3-tert-butyldimethylsilyloxymethyl-4-phenyl-5-trimethylsilylpyrazolidine

Guidance literature:: With lithium triethylborohydride; In dichloromethane; at -78 - 20 ℃; for 12h;
DOI:10.1002/(SICI)1521-3765(19990301)5:3<883::AID-CHEM883>3.0.CO;2-0

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 224572-01-4
(+)-(3S,4R,5S)-1-tert-butoxycarbonyl-3-tert-butyldimethylsilyloxymethyl-4-phenyl-5-trimethylsilylpyrazolidine

Guidance literature:: Multi-step reaction with 4 steps

2: 81 percent / NaBH₄ / methanol; tetrahydrofuran / 16 h / Ambient temperature

3: imidazole / CH₂Cl₂ / 2 h / Ambient temperature

4: 95 percent / LiBEt₃H / CH₂Cl₂ / 12 h / -78 - 20 °C

With 1H-imidazole; sodium tetrahydroborate; lithium triethylborohydride; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1002/(SICI)1521-3765(19990301)5:3<883::AID-CHEM883>3.0.CO;2-0

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 224572-01-4
(+)-(3S,4R,5S)-1-tert-butoxycarbonyl-3-tert-butyldimethylsilyloxymethyl-4-phenyl-5-trimethylsilylpyrazolidine

Guidance literature:: Multi-step reaction with 2 steps

1: imidazole / CH₂Cl₂ / 2 h / Ambient temperature

2: 95 percent / LiBEt₃H / CH₂Cl₂ / 12 h / -78 - 20 °C

With 1H-imidazole; lithium triethylborohydride; In dichloromethane;
DOI:10.1002/(SICI)1521-3765(19990301)5:3<883::AID-CHEM883>3.0.CO;2-0