(-)-(4S,5S)-1-tert-butoxycarbonyl-3-tert-butyldimethylsilyloxymethyl-4,5-dihydro-4-phenyl-5-trimethylsilyl-1H-pyrazole

Base Information

Chemical Name:(-)-(4S,5S)-1-tert-butoxycarbonyl-3-tert-butyldimethylsilyloxymethyl-4,5-dihydro-4-phenyl-5-trimethylsilyl-1H-pyrazole
CAS No.:224571-89-5
Molecular Formula:C₂₄H₄₂N₂O₃Si₂
Molecular Weight:462.78
Hs Code.:

Synonyms:(-)-(4S,5S)-1-tert-butoxycarbonyl-3-tert-butyldimethylsilyloxymethyl-4,5-dihydro-4-phenyl-5-trimethylsilyl-1H-pyrazole

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Chemical Property of (-)-(4S,5S)-1-tert-butoxycarbonyl-3-tert-butyldimethylsilyloxymethyl-4,5-dihydro-4-phenyl-5-trimethylsilyl-1H-pyrazole

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Technology Process of (-)-(4S,5S)-1-tert-butoxycarbonyl-3-tert-butyldimethylsilyloxymethyl-4,5-dihydro-4-phenyl-5-trimethylsilyl-1H-pyrazole

There total 5 articles about (-)-(4S,5S)-1-tert-butoxycarbonyl-3-tert-butyldimethylsilyloxymethyl-4,5-dihydro-4-phenyl-5-trimethylsilyl-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 224571-89-5
(-)-(4S,5S)-1-tert-butoxycarbonyl-3-tert-butyldimethylsilyloxymethyl-4,5-dihydro-4-phenyl-5-trimethylsilyl-1H-pyrazole

Guidance literature:: Multi-step reaction with 3 steps

2: 81 percent / NaBH₄ / methanol; tetrahydrofuran / 16 h / Ambient temperature

3: imidazole / CH₂Cl₂ / 2 h / Ambient temperature

With 1H-imidazole; sodium tetrahydroborate; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1002/(SICI)1521-3765(19990301)5:3<883::AID-CHEM883>3.0.CO;2-0

Reference yield:

: 119240-64-1
(1'R,2'S,5'R)-2'-(2''-phenylpropan-2''-yl)-5'-methylcyclohexyl (E)-3-phenylpropenoate

: 224571-89-5
(-)-(4S,5S)-1-tert-butoxycarbonyl-3-tert-butyldimethylsilyloxymethyl-4,5-dihydro-4-phenyl-5-trimethylsilyl-1H-pyrazole

Guidance literature:: Multi-step reaction with 4 steps

1: hexane; tetrahydrofuran / 192 h / 67 °C

2: NEt₃, DMAP / hexane; tetrahydrofuran / 2 h / Ambient temperature

3: 81 percent / NaBH₄ / methanol; tetrahydrofuran / 16 h / Ambient temperature

4: imidazole / CH₂Cl₂ / 2 h / Ambient temperature

With 1H-imidazole; dmap; sodium tetrahydroborate; triethylamine; In tetrahydrofuran; methanol; hexane; dichloromethane;
DOI:10.1002/(SICI)1521-3765(19990301)5:3<883::AID-CHEM883>3.0.CO;2-0

Reference yield:

: 196314-29-1
(-)-(1R,2S,5R)-8-phenylmenthyl 3-((4R,5S)-1-tert-butoxycarbonyl-4,5-dihydro-4-phenyl-5-trimethylsilyl-1H-pyrazole)carboxylate

: 224571-89-5
(-)-(4S,5S)-1-tert-butoxycarbonyl-3-tert-butyldimethylsilyloxymethyl-4,5-dihydro-4-phenyl-5-trimethylsilyl-1H-pyrazole

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / NaBH₄ / methanol; tetrahydrofuran / 16 h / Ambient temperature

2: imidazole / CH₂Cl₂ / 2 h / Ambient temperature

With 1H-imidazole; sodium tetrahydroborate; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1002/(SICI)1521-3765(19990301)5:3<883::AID-CHEM883>3.0.CO;2-0