1-{6-[2,3,4-trimethoxy-6-(2-methoxy-ethoxymethoxymethyl)-phenyl]-benzo[1,3]dioxol-5-yl}-ethanol

Base Information

Chemical Name:1-{6-[2,3,4-trimethoxy-6-(2-methoxy-ethoxymethoxymethyl)-phenyl]-benzo[1,3]dioxol-5-yl}-ethanol
CAS No.:693219-96-4
Molecular Formula:C₂₃H₃₀O₉
Molecular Weight:450.486
Hs Code.:

Synonyms:1-{6-[2,3,4-trimethoxy-6-(2-methoxy-ethoxymethoxymethyl)-phenyl]-benzo[1,3]dioxol-5-yl}-ethanol

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Chemical Property of 1-{6-[2,3,4-trimethoxy-6-(2-methoxy-ethoxymethoxymethyl)-phenyl]-benzo[1,3]dioxol-5-yl}-ethanol

Chemical Property:

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Technology Process of 1-{6-[2,3,4-trimethoxy-6-(2-methoxy-ethoxymethoxymethyl)-phenyl]-benzo[1,3]dioxol-5-yl}-ethanol

There total 3 articles about 1-{6-[2,3,4-trimethoxy-6-(2-methoxy-ethoxymethoxymethyl)-phenyl]-benzo[1,3]dioxol-5-yl}-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 64490-57-9
(+/-)-α-methyl-2-iodo-4,5-methylenedioxybenzyl alcohol

: 638164-12-2
4,4,5,5-tetramethyl-2-[2,3,4-trimethoxy-6-(2-methoxy-ethoxymethoxymethyl)-phenyl]-[1,3,2]dioxaborolane

: 693219-96-4
1-{6-[2,3,4-trimethoxy-6-(2-methoxy-ethoxymethoxymethyl)-phenyl]-benzo[1,3]dioxol-5-yl}-ethanol

Guidance literature:: With barium dihydroxide; DavePhos; palladium diacetate; In 1,4-dioxane; water; at 100 ℃; for 1h;
DOI:10.1055/s-2003-42039

Reference yield:

: 64490-45-5
2-iodo-3,4,5-trimethoxybenzyl alcohol

: 693219-96-4
1-{6-[2,3,4-trimethoxy-6-(2-methoxy-ethoxymethoxymethyl)-phenyl]-benzo[1,3]dioxol-5-yl}-ethanol

Guidance literature:: Multi-step reaction with 3 steps

1: 77 percent / iPr₂NEt / CH₂Cl₂ / 15 h / 0 - 25 °C

2: 84 percent / Et₃N; 2-(dicyclohexylphosphino)biphenyl / Pd(OAc)2 / dioxane / 0.5 h / 80 °C

3: Ba(OH)2; 2-(dicyclohexylphosphino)-2'-(dimethylamino)biphenyl / Pd(OAc)2 / dioxane; H₂O / 1 h / 100 °C

With barium dihydroxide; triethylamine; N-ethyl-N,N-diisopropylamine; CyJohnPhos; DavePhos; palladium diacetate; In 1,4-dioxane; dichloromethane; water; 3: Suzuki coupling;
DOI:10.1055/s-2003-42039

Reference yield:

: 638164-09-7
2-iodo-3,4,5-trimethoxy-1-(2-methoxy-ethoxymethoxymethyl)-benzene

: 693219-96-4
1-{6-[2,3,4-trimethoxy-6-(2-methoxy-ethoxymethoxymethyl)-phenyl]-benzo[1,3]dioxol-5-yl}-ethanol

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / Et₃N; 2-(dicyclohexylphosphino)biphenyl / Pd(OAc)2 / dioxane / 0.5 h / 80 °C

2: Ba(OH)2; 2-(dicyclohexylphosphino)-2'-(dimethylamino)biphenyl / Pd(OAc)2 / dioxane; H₂O / 1 h / 100 °C

With barium dihydroxide; triethylamine; CyJohnPhos; DavePhos; palladium diacetate; In 1,4-dioxane; water; 2: Suzuki coupling;
DOI:10.1055/s-2003-42039