N,N-diethyl-N-(4-(4-(ethylamino)-3-nitrobenzyl)-2-nitrophenyl)-N-(4-(methoxymethyl)-2-nitrophenyl)pyridine-2,6-dicarboxamide

Base Information

• Chemical Name: N,N-diethyl-N-(4-(4-(ethylamino)-3-nitrobenzyl)-2-nitrophenyl)-N-(4-(methoxymethyl)-2-nitrophenyl)pyridine-2,6-dicarboxamide
• CAS No.: 1396893-59-6
• Molecular Formula: C₃₄H₃₅N₇O₉
• Molecular Weight: 685.693
• Mol file: 1396893-59-6.mol

Synonyms:N,N-diethyl-N-(4-(4-(ethylamino)-3-nitrobenzyl)-2-nitrophenyl)-N-(4-(methoxymethyl)-2-nitrophenyl)pyridine-2,6-dicarboxamide

Chemical Property of N,N-diethyl-N-(4-(4-(ethylamino)-3-nitrobenzyl)-2-nitrophenyl)-N-(4-(methoxymethyl)-2-nitrophenyl)pyridine-2,6-dicarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N,N-diethyl-N-(4-(4-(ethylamino)-3-nitrobenzyl)-2-nitrophenyl)-N-(4-(methoxymethyl)-2-nitrophenyl)pyridine-2,6-dicarboxamide

There total 8 articles about N,N-diethyl-N-(4-(4-(ethylamino)-3-nitrobenzyl)-2-nitrophenyl)-N-(4-(methoxymethyl)-2-nitrophenyl)pyridine-2,6-dicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

6-(ethyl(4-(methoxymethyl)-2-nitrophenyl)carbamoyl)picolinic acid (1396893-58-5) + 3,3′-dinitro-4,4′-di(N-ethylamino)diphenylmethane (101588-67-4) → N,N-diethyl-N-(4-(4-(ethylamino)-3-nitrobenzyl)-2-nitrophenyl)-N-(4-(methoxymethyl)-2-nitrophenyl)pyridine-2,6-dicarboxamide (1396893-59-6)

Guidance literature:

6-(ethyl(4-(methoxymethyl)-2-nitrophenyl)carbamoyl)picolinic acid; With thionyl chloride; N,N-dimethyl-formamide; In dichloromethane; for 1.5h; Reflux;

3,3′-dinitro-4,4′-di(N-ethylamino)diphenylmethane; With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 12h; Inert atmosphere; Reflux;

DOI:10.1021/ic301631n

Reference yield:

N-Ethyl-2-nitroaniline (10112-15-9) → N,N-diethyl-N-(4-(4-(ethylamino)-3-nitrobenzyl)-2-nitrophenyl)-N-(4-(methoxymethyl)-2-nitrophenyl)pyridine-2,6-dicarboxamide (1396893-59-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride

2.1: N,N-dimethyl-formamide; thionyl chloride / dichloromethane / 1.5 h / Reflux

2.2: 12 h / Inert atmosphere; Reflux

With hydrogenchloride; thionyl chloride; N,N-dimethyl-formamide; In dichloromethane;

DOI:10.1021/ic301631n

Reference yield:

1-chloro-4-methoxymethyl-2-nitrobenzene (118172-76-2) → N,N-diethyl-N-(4-(4-(ethylamino)-3-nitrobenzyl)-2-nitrophenyl)-N-(4-(methoxymethyl)-2-nitrophenyl)pyridine-2,6-dicarboxamide (1396893-59-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: water

2.1: N,N-dimethyl-formamide; thionyl chloride / dichloromethane / 1 h / Inert atmosphere; Reflux

2.2: 2 h / Inert atmosphere; Reflux

3.1: lithium hydroxide / water; methanol / 3 h / 0 °C

3.2: pH 2

4.1: N,N-dimethyl-formamide; thionyl chloride / dichloromethane / 1.5 h / Reflux

4.2: 12 h / Inert atmosphere; Reflux

With thionyl chloride; N,N-dimethyl-formamide; lithium hydroxide; In methanol; dichloromethane; water;

DOI:10.1021/ic301631n

upstream raw materials:

6-(methoxycarbonyl)pyridine-2-carboxylic acid

methyl 6-(ethyl(4-(methoxymethyl)-2-nitrophenyl)carbamoyl)picolinate

6-(ethyl(4-(methoxymethyl)-2-nitrophenyl)carbamoyl)picolinic acid

3,3′-dinitro-4,4′-di(N-ethylamino)diphenylmethane

Downstream raw materials:

N-(4-(4-(6-(diethylcarbamoyl)-N-ethylpicolinamido)-3-nitrobenzyl)-2-nitrophenyl)-N,N-diethyl-N-(4-(methoxymethyl)-2-nitrophenyl)pyridine-2,6-dicarboxamide