N-(4-(4-(6-(diethylcarbamoyl)-N-ethylpicolinamido)-3-nitrobenzyl)-2-nitrophenyl)-N,N-diethyl-N-(4-(methoxymethyl)-2-nitrophenyl)pyridine-2,6-dicarboxamide

Base Information

• Chemical Name: N-(4-(4-(6-(diethylcarbamoyl)-N-ethylpicolinamido)-3-nitrobenzyl)-2-nitrophenyl)-N,N-diethyl-N-(4-(methoxymethyl)-2-nitrophenyl)pyridine-2,6-dicarboxamide
• CAS No.: 1396893-60-9
• Molecular Formula: C₄₅H₄₇N₉O₁₁
• Molecular Weight: 889.922
• Mol file: 1396893-60-9.mol

Synonyms:N-(4-(4-(6-(diethylcarbamoyl)-N-ethylpicolinamido)-3-nitrobenzyl)-2-nitrophenyl)-N,N-diethyl-N-(4-(methoxymethyl)-2-nitrophenyl)pyridine-2,6-dicarboxamide

Chemical Property of N-(4-(4-(6-(diethylcarbamoyl)-N-ethylpicolinamido)-3-nitrobenzyl)-2-nitrophenyl)-N,N-diethyl-N-(4-(methoxymethyl)-2-nitrophenyl)pyridine-2,6-dicarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-(4-(6-(diethylcarbamoyl)-N-ethylpicolinamido)-3-nitrobenzyl)-2-nitrophenyl)-N,N-diethyl-N-(4-(methoxymethyl)-2-nitrophenyl)pyridine-2,6-dicarboxamide

There total 11 articles about N-(4-(4-(6-(diethylcarbamoyl)-N-ethylpicolinamido)-3-nitrobenzyl)-2-nitrophenyl)-N,N-diethyl-N-(4-(methoxymethyl)-2-nitrophenyl)pyridine-2,6-dicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

N,N-diethyl-N-(4-(4-(ethylamino)-3-nitrobenzyl)-2-nitrophenyl)-N-(4-(methoxymethyl)-2-nitrophenyl)pyridine-2,6-dicarboxamide (1396893-59-6) + 2-(hydroxycarbonyl)-6-[(N,N-diethylamino)carbonyl]pyridine (179469-06-8) → N-(4-(4-(6-(diethylcarbamoyl)-N-ethylpicolinamido)-3-nitrobenzyl)-2-nitrophenyl)-N,N-diethyl-N-(4-(methoxymethyl)-2-nitrophenyl)pyridine-2,6-dicarboxamide (1396893-60-9)

Guidance literature:

2-(hydroxycarbonyl)-6-[(N,N-diethylamino)carbonyl]pyridine; With thionyl chloride; N,N-dimethyl-formamide; In dichloromethane; for 1.5h; Reflux;

N,N-diethyl-N-(4-(4-(ethylamino)-3-nitrobenzyl)-2-nitrophenyl)-N-(4-(methoxymethyl)-2-nitrophenyl)pyridine-2,6-dicarboxamide; With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 12h; Inert atmosphere; Reflux;

DOI:10.1021/ic301631n

Reference yield:

6-(methoxycarbonyl)pyridine-2-carboxylic acid (7170-36-7) → N-(4-(4-(6-(diethylcarbamoyl)-N-ethylpicolinamido)-3-nitrobenzyl)-2-nitrophenyl)-N,N-diethyl-N-(4-(methoxymethyl)-2-nitrophenyl)pyridine-2,6-dicarboxamide (1396893-60-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: N,N-dimethyl-formamide; thionyl chloride / dichloromethane / 1 h / Reflux

1.2: 2 h / Reflux

2.1: sodium hydroxide / water / 0.17 h

2.2: pH 2

3.1: N,N-dimethyl-formamide; thionyl chloride / dichloromethane / 1.5 h / Reflux

3.2: 12 h / Inert atmosphere; Reflux

With thionyl chloride; N,N-dimethyl-formamide; sodium hydroxide; In dichloromethane; water;

DOI:10.1021/ic301631n

Reference yield:

Pyridine-2,6-dicarboxylic acid (499-83-2) → N-(4-(4-(6-(diethylcarbamoyl)-N-ethylpicolinamido)-3-nitrobenzyl)-2-nitrophenyl)-N,N-diethyl-N-(4-(methoxymethyl)-2-nitrophenyl)pyridine-2,6-dicarboxamide (1396893-60-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sulfuric acid

2.1: N,N-dimethyl-formamide; thionyl chloride / dichloromethane / 1 h / Reflux

2.2: 2 h / Reflux

3.1: sodium hydroxide / water / 0.17 h

3.2: pH 2

4.1: N,N-dimethyl-formamide; thionyl chloride / dichloromethane / 1.5 h / Reflux

4.2: 12 h / Inert atmosphere; Reflux

With thionyl chloride; sulfuric acid; N,N-dimethyl-formamide; sodium hydroxide; In dichloromethane; water;

DOI:10.1021/ic301631n

upstream raw materials:

6-(methoxycarbonyl)pyridine-2-carboxylic acid

methyl 6-(ethyl(4-(methoxymethyl)-2-nitrophenyl)carbamoyl)picolinate

6-(ethyl(4-(methoxymethyl)-2-nitrophenyl)carbamoyl)picolinic acid

N-Ethyl-2-nitroaniline