methyl 6-(ethyl(4-(methoxymethyl)-2-nitrophenyl)carbamoyl)picolinate

Base Information

• Chemical Name: methyl 6-(ethyl(4-(methoxymethyl)-2-nitrophenyl)carbamoyl)picolinate
• CAS No.: 1396893-57-4
• Molecular Formula: C₁₈H₁₉N₃O₆
• Molecular Weight: 373.365
• Mol file: 1396893-57-4.mol

Synonyms:methyl 6-(ethyl(4-(methoxymethyl)-2-nitrophenyl)carbamoyl)picolinate

Chemical Property of methyl 6-(ethyl(4-(methoxymethyl)-2-nitrophenyl)carbamoyl)picolinate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 6-(ethyl(4-(methoxymethyl)-2-nitrophenyl)carbamoyl)picolinate

There total 4 articles about methyl 6-(ethyl(4-(methoxymethyl)-2-nitrophenyl)carbamoyl)picolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

6-(methoxycarbonyl)pyridine-2-carboxylic acid (7170-36-7) + N-ethyl-(4-methoxymethyl-2-nitrophenyl)amine (218143-44-3) → methyl 6-(ethyl(4-(methoxymethyl)-2-nitrophenyl)carbamoyl)picolinate (1396893-57-4)

Guidance literature:

6-(methoxycarbonyl)pyridine-2-carboxylic acid; With thionyl chloride; N,N-dimethyl-formamide; In dichloromethane; for 1h; Inert atmosphere; Reflux;

N-ethyl-(4-methoxymethyl-2-nitrophenyl)amine; With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 2h; Inert atmosphere; Reflux;

DOI:10.1021/ic301631n

Reference yield:

1-chloro-4-methoxymethyl-2-nitrobenzene (118172-76-2) → methyl 6-(ethyl(4-(methoxymethyl)-2-nitrophenyl)carbamoyl)picolinate (1396893-57-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: water

2.1: N,N-dimethyl-formamide; thionyl chloride / dichloromethane / 1 h / Inert atmosphere; Reflux

2.2: 2 h / Inert atmosphere; Reflux

With thionyl chloride; N,N-dimethyl-formamide; In dichloromethane; water;

DOI:10.1021/ic301631n

Reference yield:

4-chloro-3-nitrobenzyl alcohol (55912-20-4) → methyl 6-(ethyl(4-(methoxymethyl)-2-nitrophenyl)carbamoyl)picolinate (1396893-57-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium hydroxide

2.1: water

3.1: N,N-dimethyl-formamide; thionyl chloride / dichloromethane / 1 h / Inert atmosphere; Reflux

3.2: 2 h / Inert atmosphere; Reflux

With thionyl chloride; N,N-dimethyl-formamide; potassium hydroxide; In dichloromethane; water;

DOI:10.1021/ic301631n

upstream raw materials:

6-(methoxycarbonyl)pyridine-2-carboxylic acid

N-ethyl-(4-methoxymethyl-2-nitrophenyl)amine

4-chloro-3-nitrobenzyl alcohol

1-chloro-4-methoxymethyl-2-nitrobenzene

Downstream raw materials:

6-(ethyl(4-(methoxymethyl)-2-nitrophenyl)carbamoyl)picolinic acid

N,N-diethyl-N-(4-(4-(ethylamino)-3-nitrobenzyl)-2-nitrophenyl)-N-(4-(methoxymethyl)-2-nitrophenyl)pyridine-2,6-dicarboxamide

N-(4-(4-(6-(diethylcarbamoyl)-N-ethylpicolinamido)-3-nitrobenzyl)-2-nitrophenyl)-N,N-diethyl-N-(4-(methoxymethyl)-2-nitrophenyl)pyridine-2,6-dicarboxamide