methyl (2S)-2-(tert-butoxycarbonylmethyl-amino)-3-(4-tert-butoxy-phenyl)-propionate

Base Information

Chemical Name:methyl (2S)-2-(tert-butoxycarbonylmethyl-amino)-3-(4-tert-butoxy-phenyl)-propionate
CAS No.:1278457-61-6
Molecular Formula:C₂₀H₃₁NO₅
Molecular Weight:365.47
Hs Code.:

Synonyms:methyl (2S)-2-(tert-butoxycarbonylmethyl-amino)-3-(4-tert-butoxy-phenyl)-propionate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl (2S)-2-(tert-butoxycarbonylmethyl-amino)-3-(4-tert-butoxy-phenyl)-propionate

Chemical Property:

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Technology Process of methyl (2S)-2-(tert-butoxycarbonylmethyl-amino)-3-(4-tert-butoxy-phenyl)-propionate

There total 1 articles about methyl (2S)-2-(tert-butoxycarbonylmethyl-amino)-3-(4-tert-butoxy-phenyl)-propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 5292-43-3
bromoacetic acid tert-butyl ester

: 52616-82-7
O-tert-butyl-L-tyrosine methyl ester

: 1278457-61-6
methyl (2S)-2-(tert-butoxycarbonylmethyl-amino)-3-(4-tert-butoxy-phenyl)-propionate

Guidance literature:: With sodium carbonate; In acetonitrile; at 20 ℃; for 18h;
DOI:10.1016/j.bmc.2010.07.064

Reference yield: 55.0%

: 1278457-61-6
methyl (2S)-2-(tert-butoxycarbonylmethyl-amino)-3-(4-tert-butoxy-phenyl)-propionate

: 146432-43-1
N-(2-bromoethyl)-N-[2-(1,1-dimethylethoxy)-2-oxoethyl]glycine 1,1-dimethylethyl ester

: 1278457-65-0
methyl (2S)-2-((2-(bis-(tert-butoxycarbonylmethyl)amino)-ethyl)-(tert-butoxycarbonylmethyl)-amino)-3-(4-tertbutoxy-phenyl)-propionate

Guidance literature:: With sodium carbonate; In acetonitrile; for 48h; Reflux;
DOI:10.1016/j.bmc.2010.07.064

Reference yield:

: 1278457-61-6
methyl (2S)-2-(tert-butoxycarbonylmethyl-amino)-3-(4-tert-butoxy-phenyl)-propionate

: (2S)-2-((2-(bis-carboxymethyl-amino)-ethyl)-carboxymethyl-amino)-3-(4-hydroxy-phenyl)-propionic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium carbonate / acetonitrile / 48 h / Reflux

2.1: water; potassium hydroxide / methanol / 8 h / 20 °C

2.2: pH 2 / Acidic conditions

2.3: 18 h / 20 °C

With water; sodium carbonate; potassium hydroxide; In methanol; acetonitrile;
DOI:10.1016/j.bmc.2010.07.064